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| Diagnostic Value of Combined Detection of CRP, sCD14-ST and NAP in Children with Respiratory Tract Infectious Diseases |
| LIU Ping-ding, YANG Fang-yi |
| Department of Pediatrics, Weinan Maternal and Child Health Hospital, Weinan Shaanxi, 714000 |
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Abstract 【Objective】To investigate the diagnostic value of combined detection of C-reactive protein (CRP), soluble cluster of differentiation 14 subtype (sCD14-ST) and neutrophil alkaline phosphatase (NAP) in children with respiratory tract infections. 【Methods】A total of 50 children with respiratory tract infections (as observation group) and 50 healthy children with health examination (as control group) in our hospital were selected for the study. Serum CRP, sCD14-ST levels and NAP scores were compared between the two groups, and the scores of CRP, sCD14-ST and NAP were also analyzed in sick children infected by different pathogens. The correlation among CRP,sCD14-ST and NAP was analyzed, and the diagnostic efficacy of CPR, sCD14-ST and NAP for respiratory infection was compared as well. 【Results】The serum CRP, sCD14-ST levels and NAP scores in the observation group were significantly higher than those in the control group (P<0.05). Serum CRP, sCD14-ST levels and NAP scores were significantly different in children with respiratory tract infection caused by different pathogens (P<0.05). The levels of serum CRP, sCD14-ST and NAP scores of children with bacterial respiratory infections were significantly higher than those of children with viral and mycoplasma respiratory tract infections, and the difference was significant (P<0.05). And serum CRP, sCD14-ST and NAP levels of children with viral respiratory tract infections were significantly higher than those of children with mycoplasma infection (P<0.05). The results showed that CRP was positively correlated with sCD14-ST and NAP (P<0.05), moreover, sCD14-ST was positively correlated with NAP (P<0.05). CRP, sCD14-ST and NAP were independent risk factors for respiratory infection (P<0.05); The diagnostic efficacy of combined detection of the three for respiratory tract infection was significantly better than that of individual detection (P<0.05). 【Conclusion】Serum CRP, sCD14-ST levels and NAP scores are significantly elevated in children with respiratory tract infections. The combined detection of the three can improve the diagnosis efficacy.
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Received: 17 May 2020
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1241-1243. |
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2021, Vol. 38 
