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| Predictive Value of Thrombelastography on Pregnancy Rate of Patients with Early Recurrent Spontaneous Abortion |
| LI Hui-liang, TANG Xin-qiao, CAI Dan |
| Xiangtan City Central Hospital,Xiangtan Hunan 411100 China |
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Abstract 【Objective】 To explore the application of thromboelastography to predict the pregnancy rate of patients with early recurrent spontaneous abortion (RSA). 【Methods】 A total of 72 RSA patients from January 2016 to December 2017 in our hospital were selected and randomly divided into group A and group B with 36 cases in each group. In addition, 40 normal pregnant women in the same period were selected as group C (the control group). Patients in the group A received both aspirin and low molecular weight heparin calcium, while patients in the group B only received aspirin treatment. RSA patients of both groups started taking the medication two months before the planned pregnancy and continued the medication until 1 month after pregnancy. Thromboelastogram in both group A and B was detected before therapy and after drug withdrawal, while in control group thromboelastogram was detected before pregnancy and 1 month after pregnancy. Thromboelastogram was followed up for 12 months. Thromboelastogram index and pregnancy loss rate were compared among groups before and after pregnancy. The correlation between thromboelastogram parameters and pregnancy loss rate were analyzed. 【Results】 Before pregnancy, the R value and alpha (α) angle of group A and B were significantly lower than those of Group C, while the MA value and K value of group A and B were significantly higher than Group C. The differences were statistically significant (P<0.05).The R value and α angle in group A were lower than those in group B, while K value in group A was higher than in group B. The differences were statistically significant (P<0.05), however, the MA value in group A and group B dii not show significant difference (P>0.05). After pregnancy, the R value and α angle of group A and group C were significantly higher than that of group B, and the K value and MA value were significantly lower than group B. The differences were statistically significant (P<0.05). The K value, alpha angle and MA value in group A and C had no significant difference (P>0.05). The pregnancy loss rates in group A,B and C were 16.7% (6/36), 38.9% (14/36) and 2.5% (1/40), respectively. The pregnancy loss rate showing group C < group A < group B, so there were significant differences among groups (P<0.05). According to the analysis of binary Logistic regression model, pregnancy loss rate was significantly correlated with MA value (r=0.614, P<0.05), but was not significantly correlated with the R value, K value and α angle. 【Conclusion】 Thromboelastography can detect the pre-thrombotic state of patients with early recurrent spontaneous abortion and predict the pregnancy loss rate . It is worth popularizing and applying in clinic.
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Received: 28 April 2019
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2020, Vol. 37 
