Abstract【Objective】 To investigate the effect of sufentanil target-controlled infusion on postoperative analgesia, stress response and immune function after laparoscopic surgery. 【Methods】 A total of 82 patients with laparoscopic surgeries in our hospital were collected in the study. The randomized digital table was used to divide these cases into the control group (n=42) and the observation group (n=40). Patients in the control group received intravenous analgesia after operation, while patients in the observation group received the target-controlled analgesic of citrate sufentanil after operation. The postoperative sedation and analgesia scores of the two groups were compared, meanwhile, the concentrations of substance P and β endorphin and levels of CD4+, CD8+, CD4+/CD8+ were measured before and after treatment.【Results】 The analgesia and sedation scores between the two groups had significant difference (P<0.05). After treatment, the level of substance P in the observation group was significantly lower, while the level of β-endorphin in the observation group was higher than that in the control group and before treatment (P<0.05). The level of CD4+ in observation group after treatment was lower than that before treatment, and the CD4+ level in the observation group was also lower than that in the control group (P<0.05). The levels of CD8+ and CD4+/CD8+ had no significant difference between the two groups (P>0.05). 【Conclusion】 The application of the sufentanil target-controlled infusion shows good postoperative analgesia effect, which reduces the postoperative stress response and immune function regulation for patients after laparoscopic surgery. It is worthy of further clinical promotion.
LIAO Hai-ming,YU Fan,DENG Qing-shan, et al. Effect of Sufentanil Target-Controlled Infusion on Postoperative Analgesia, Stress Response and Immune Function after Laparoscopic Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(5): 708-711.
2020, Vol. 37 
