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| Relationship between CD64 and Wagner Grade of Diabetic Foot Ulcer |
| SUN Hao-jie, GENG Hou-fa, LIANG Jun |
| Department of Endocrinology,Xuzhou Central Hospital,Xuzhou Jiangsu 221000 |
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Abstract 【Objective】 To explore the relationship between peripheral blood CD64 level and Wagner grading level of diabetic foot. 【Methods】 From November 2017 to December 2018, 162 patients with diabetic foot were divided into two groups according to the Wagner classification (severity): Wagner 2-3 (93 cases, group A), Wagner 4-5 (69 cases, group B). The levels of peripheral blood CD64, serum procalcitonin (PCT), C-reactive protein (CRP) and leukocyte (WBC) were compared between the two groups, The correlation between peripheral blood CD64 and other indexes was analyzed, and the relationship between CD64 and Wagner grade of diabetic foot was analyzed by logistic regression. The ROC curve was drawn, the area under the curve was calculated, and the sensitivity and specificity of CD64 in predicting the severity of diabetic foot were analyzed.【Results】 The levels of CD64, CRP, PCT and WBC in the group A were significantly higher than those in the group B (P<0.05). The correlation analysis showed that CD64 was positively correlated with CRP, PCT and WBC (r=0.86, 0.84, 0.62, respectively; P<0.05). Multivariate logistic regression analysis: the course of diabetic foot, CD64 and smoking were independent risk factors for the severity of diabetic foot disease (P<0.05). The area under ROC curve (0.892) showed that CD64 was related to the severity of diabetic foot. According to the maximum Youden index, when the critical value of CD64 was 3.38, its sensitivity was 81.2%, and its specificity was 91.4%.【Conclusion】 CD64 is related to Wagner's grade of diabetic foot, and high expression level of CD64 indicates that the condition of diabetic foot is more serious.
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Received: 09 April 2019
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2020, Vol. 37 
