Abstract 【Objective】To investigate the efficacy of thoracoscopic single-hole and three-hole pneumonectomy in patients with early non-small cell lung cancer (NSCLC) and their effects on interleukin-8 (IL-8), irregular chemokines (Fractalkine) and human macrophage inflammatory protein 3α (MIP-3α) levels. 【Methods】Patients with early non-small cell lung cancer who underwent thoracoscopic pneumonectomy at our hospital were selected. The surgical methods were thoracoscopic single-hole and three-hole pneumonectomy. The general surgical information, lung function, IL-8, Fractalkine, MIP-3α, postoperative recovery and 1-year survival rate were compared between the two groups. 【Results】 The intraoperative blood loss and the time to get out of bed after operation in patients of the single-hole operation group were lower than those of the three-hole operation group (P<0.05). There were no significant differences in the operation time, number of lymph nodes dissipated, and time to remove the thoracic drainage tube between the two groups (P>0.05). Levels of IL-8, Fractalkine and MIP-3α before surgery did not show significant differences between the two groups (P>0.05). After surgery, the levels of IL-8, Fractalkine, and MIP-3α in the single-hole operation group level was lower than those in the three-hole operation group; and the differences were statistically significant (P<0.05). There were no significant differences of lung function-related indicators: forced expiratory velocity at the first second (FEV1), forced vital capacity (FVC), and maximum voluntary ventilation (MVV) levels before and after surgery between the two groups of patients (P>0.05). The one-year survival rates of the two groups were 75.00% and 72.50%, respectively, which had no significant difference (P<0.05). The number of postoperative lung infections, nerve injuries and chest pain in the two groups were no significant difference as well (P>0.05). 【Conclusion】Thoracoscopic single-hole and three-hole pneumonectomy are similarly effective for patients with early non-small cell lung cancer. However, single-hole surgery has less trauma and can lower levels of IL-8, Fractalkine and MIP-3α, which has good application value.
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2020, Vol. 37 
