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| Effect of Serum Thyroid Stimulating Hormone Level on Risk of Cardiovascular Disease in Patients with Type 2 Diabetes Combined with Subclinical Hypothyroidism |
| ZHANG Xia |
| Wuxi eighth people's hospital ,Wuxi Jiangsu 214000 |
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Abstract 【Objective】To investigate the effect of serum thyroid stimulating hormone levels on the risk of cardiovascular disease in type 2 diabetes patients with subclinical hypothyroidism. 【Methods】One hundred T2DM patients with subclinical hypothyroidism who were treated in our hospital from January 2014 to January 2017 were divided into two groups according to the TSH level at the time of admission: the TSH increased group (TSH > 5.6 IU/mL, n=28) and the TSH normal group (TSH ≤ 5.6 IU/mL, n=72). The incidence rate of cardiovascular disease in two groups was compared, and the correlation between TSH level and clinical index was analyzed. Multivariate Logistic regression analysis was performed to analyze the risk factors of cardiovascular events.【Results】The levels of free triiodothyronine (FT3) and free thyroxine (FT4) in the TSH increased group were significantly lower than those in the TSH normal group (P<0.05); the incidence of cardiovascular events in the TSH increased group was 39.29% (11 / 28), higher than 13.89% (10/72) in the TSH normal group (P<0.05). TSH level was positively correlated with systolic blood pressure at admission (P<0.05), and negatively correlated with FT3 and FT4 (P<0.05). Multiple logistic regression analysis showed that: uric acid, systolic blood pressure, TSH, FT3, triglyceride (TG) were the risk factors of cardiovascular disease.【Conclusion】Serum TSH levels are significantly associated with the risk of cardiovascular disease in type 2 diabetes patients with subclinical hypothyroidism.
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Received: 15 April 2019
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2020, Vol. 37 
