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| Effect of Etomidate Emulsion on Anesthesia Recovery and changes of MAP and HR in Patients undergoing Laparoscopic Hysterectomy |
| HAN Yao-ming, HAN Jing-tian, JIN Gang,et al |
| Fu Mining General Hospital of Liaoning Health Industry Group department of anesthesiology,Liaoning Fushun 113008 |
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Abstract 【Objective】To investigate the effects of etomidate emulsion on anesthesia recovery and changes of mean arterial pressure (MAP) and heart rate (HR) in patients undergoing laparoscopic uterine surgery.【Methods】A total of 120 patients undergoing laparoscopic hysterectomy were divided into two groups according to anesthesia methods. Patients in the control group received propofol combined with remifentanil by intravenous anesthesia, while patients in the observation group received etomidate emulsion combined with remifentanil by intravenous anesthesia. The anesthesia and operation procedure of the two groups were compared.【Results】MAP, HR level, PI (pulsatility index) and MCA-PSV (peak systolic velocity of middle cerebral artery) showed no significant differences between the two groups before anesthesia (T0), immediately after endotracheal intubation (T1),10 min after no pneumoperitoneum in supine position (T3) (P >0.05). The MAP level at T2 (low head position with pneumoperitoneum) in the observation group was lower than that in the control group, however, the HR, MCA-PSV and PI in the observation group were not significant from the control group (P>0.05). Eye opening time, tracheal extubation time and disorientation timer in observation group was shorter than those in the control group; and the differences between the two groups were statistically significant (P<0.05). The incidence of nausea and vomiting in the observation group was 1.67% (1/60) and the incidence of muscle fibrillation was 1.67% (1/60), which were not significant difference with those in the control group (P> 0.05). The incidence of injection pain in the observation group was 0.00% (0/60), which was lower than that in the control group (10.00%, 6/60) (P<0.05).【Conclusion】The application of etomidate emulsion in laparoscopic hysterectomy can promote the recovery of anesthesia. It has little effect on the cerebral blood flow, MAP and HR.
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Received: 11 June 2019
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2020, Vol. 37 
