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| Distribution of Integrons and Drug Resistance of Carbapenem-resistant Escherichia Coli in Elderly Patients with Urinary Tract Infection |
| XU Yan, CHEN Jian |
| Department of clinical laboratory, Hunan Provincial People's Hospital/ the Affiliated Hospital of Hunan Normal University, Changsha , Hunan, 410016 China |
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Abstract 【Objective】To investigate the distribution of integron and drug resistance of carbapenem resistant Escherichia coli (CREco) in elderly patients with UTI.【Methods】E.coli was isolated from urine of UTI patients in our hospital from January 2016 to January 2020. Vitek-2 system was used to identify and detect drug sensitivity. The phenotype of the strains was confirmed by improved Hodge test, and the distribution of integrons was detected by PCR.【Results】A total of 610 strains of E.coli were isolated from urine samples of patients. The cases were mainly distributed in intensive care unit (22.63%), urology department (16.23%), rehabilitation department (13.93%), endocrinology department (13.13%), geriatrics department (11.64%); 68 strains of CREco were detected, accounting for 11.15% (68/610). The drug resistance of CREco strains was significantly higher than that of non CREco strains (P<0.05). Among 284 strains of E.coli with multiple drug resistance, 163 strains were positive for class Ⅰ integron, the detection rate was 57.39%, no class Ⅱ and Ⅲ integron were detected, among which 68 CREco strains were detected type Ⅰ integron. The distribution of class Ⅰ integron in CREco was significantly higher than that in non CREco group (P<0.01). 【Conclusion】The drug resistance of CREco in elderly UTI patients is serious, which is related to the high distribution of class Ⅰ integrons in patients. It is necessary to strictly and rationally use drugs in clinic to avoid the spread and outbreak of CREco.
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Received: 12 August 2020
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2020, Vol. 37 
