Abstract【Objective】 To investigate the clinical effect of traditional Chinese medicine (TCM) Yiqi-Huoxue (invigorating qi and activating blood circulation) combined with paclitaxel and carbohydrates in the treatment of ovarian cancer and the changes of related factors. 【Methods】 A total of 82 patients with ovarian cancer treated in our hospital from May 2016 to February 2019 were randomly divided into two groups with 41 cases in each. The control group was treated with paclitaxel combined with carboplatin, and the observation group was treated with traditional Chinese medicine Yiqi-Huoxue for invigorating qi and activating blood circulation on the basis of the control group. The clinical effect of the two groups after treatment was analyzed. 【Results】 The overall effective rate in the observation group (73.17%) was higher than that in the control group (51.22%), and the difference was statistically significant (P<0.05). There was no significant difference in tumor markers and cellular immune indexes between the two groups before treatment (P>0.05). After treatment, the levels of IL-2 (IL-2) and interferon-gamma (INF- γ) in the observation group were higher than those in the control group (P<0.05), and the levels of carbohydrate antigen (CA199), carbohydrate antigen (CA125), human epididymal protein 4 (HE4) and IL-10 (IL-10) were lower than those in the control group (P<0.05). There was no significant difference in TCM syndrome score and Karst (KPS) score between the two groups before treatment (P>0.05). After treatment, the score of KPS in the observation group (79.69±6.14) was higher than that in the control group (68.59±5.20), and the score of TCM syndromes (13.02±2.89) in the observation group was lower than that in the control group (17.98±3.28; P<0.05). 【Conclusion】 Traditional Chinese medicine for invigorating qi and activating blood circulation combined with paclitaxel can improve the cellular immune level, decrease the expression level of tumor markers and improve the quality of life in patients with ovarian cancer.
TAN Chang-an,WU Jin-hua,LI Xiao-li. Clinical Efficacy of Chinese Medicine Combined with Paclitaxel and Carboplatin in the Treatment of Ovarian Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1548-1551.
2020, Vol. 37 
