Abstract【Objective】 To investigate value of diagnosis and application of high-sensitivity troponin I (hs-cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP) and D-dimer (D-D) in patients with acute cerebral hemorrhage. 【Methods】 A total of 63 patients with acute cerebral hemorrhage were selected as the observation group, meanwhile, 63 healthy volunteers who were admitted to our hospital for physical examination at the same period were selected as the control group. The levels of hs-cTnI, NT-proBNP and D-D in both control and observation groups were detected before treatment. According to the volume of hemorrhage, patients in the observation group were further divided into small, moderate and severe hemorrhage sub-groups. After 7 days of treatment, levels of hs-cTnI, NT-proBNP and D-D in patients were detected again. ROC curves of hs-cTnI, NT-proBNP and D-D were drawn to analyze the efficacy in diagnosis of acute cerebral hemorrhage. 【Results】 The levels of hs-cTnI, NT-proBNP and D-D in observation group were higher than those in control group (P<0.01). Compared to before treatment, the levels of hs-cTnI, NT-proBNP and D-D in observation group decreased after treatment. The levels of hs-cTnI, NT-proBNP and D-D in the small hemorrhage sub-group were lower than those in the moderate hemorrhage sub-group and severe hemorrhage sub-group (P<0.05); And the levels of hs-cTnI, NT-proBNP and D-D in the moderate hemorrhage sub-group were lower than that in the severe hemorrhage sub-group (P<0.05). The sensitivity and specificity in the combined determination of hs-cTnI, NT-proBNP and D-D was higher than any single hs-cTnI, NT-proBNP, or D-D application in the diagnosis of acute cerebral hemorrhage (P<0.05). 【Conclusion】 The serum levels of hs-cTnI, NT-proBNP and D-D in patients with acute cerebral hemorrhage rapidly increase. With the condition improves after treatment, serum hs-cTnI, NT-proBNP and D-D levels decrease. Application of hs-cTnI, NT-proBNP, and D-D combination can provide better assessment of acute cerebral hemorrhage prognosis and guidance of clinical treatment.
MA De-jia,LI Yan-ni,HAN Yu-jian. Application of hs-cTnI , NT-proBNP and D-D in Patients with Acute Cerebral Hemorrhage[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1468-1470.
2020, Vol. 37 
