高血压患者的血浆动脉硬化指数与尿酸水平的相关性研究

doi:10.3969/j.issn.1671-7171.2020.10.004

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Abstract 【Objective】 To investigate the relationship between plasma arteriosclerosis index (AIP) and uric acid level in patients with different grades of hypertension.【Methods】 A total of 443 patients with hypertension who were treated for the first time in the Department of cardiovascular medicine of our hospital from January to December 2018 wae selected as the research objects. According to the classification standard of hypertension, the patients were divided into three groups:hypertension group 1 (n=102), hypertension group 2 (n=177), hypertension group 3 (n=164). The blood biochemical indexes were detected by automatic blood cell and biochemical immune analyzer, and the general clinical data of patients were recorded at the same time.【Results】 There were significant differences in age, body mass index (BMI), uric acid (UA), creatinine (CR), cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and plasma atherosclerotic index (AIP) among the three groups. There were significant differences in the levels of hypertension, UA, TG, non-HDL-C, HDL-C, ApoA1 and AIP between the hyperuricemia group and the non hyperuricemia group (P<0.05). Spearman correlation analysis showed that UA was positively correlated with AIP, TG, non-HDL-C and apoB (P<0.05), and negatively correlated with HDL-C and ApoA1 (P<0.05). AIP was positively correlated with UA in patients with grade 3, 2 and 1 hypertension (r₃=0.617, P<0.01; r₂=0.59, P<0.01;r₁=0.35, P<0.01). AIP had a good predictive value for patients with hyperuricemia (P<0.01). The area under ROC curve AUC=0.855, 95% CI(0.815, 0.895), sensitivity 87.5%, specificity 73.5%.【Conclusion】 AIP is positively correlated with the UA level of hypertension patients. Under different hypertension grades, the blood uric acid level and AIP level of patients have significant differences. The higher the grading, the higher the level of AIP and the higher the level of blood uric acid.

Key words： Hypertension Arteriosclerosis Uric Acid

Received: 04 February 2020

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R544.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.10.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I10/1454

[1] Wang Z, Chen Z, Zhang L, et al. Status of Hypertension in China: Results From the China Hypertension Survey, 2012-2015[J].Circulation,2018,137(22):2344-2356.
[2] 高血压患者胆固醇管理临床指导建议专家组. 高血压患者胆固醇管理临床指导建议[J].中华内科杂志,2010,49(2):186-190.
[3] 高尿酸血症相关疾病诊疗多学科共识专家组. 中国高尿酸血症相关疾病诊疗多学科专家共识[J].中华内科杂志,2017,56(3):235-248.
[4] Borghi C, Tykarski A, Widecka K, et al. Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk[J].Cardiol J,2018,25(5):545-563.
[5] Tan MH, Johns D, Glazer NB. Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes[J].Clin Chem,2004,50(7):1184-1188.
[6] Cai G, Shi G, Xue S, et al. The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population[J].Medicine,2017,96(37):e8058.
[7] 中国高血压防治指南修订委员会,中华医学会心血管病学分会高血压联盟中国,中国医师协会高血压专业委员会,等. 中国高血压防治指南(2018年修订版)[J].中国心血管杂志,2019,24(1):24-56.
[8] Biscaglia S, Ceconi C, Malagu M, et al. Uric acid and coronary artery disease: An elusive link deserving further attention[J].Int J Cardiol,2016,213:28-32.
[9] Cao Z, Cheng Y, Li S, et al. Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study[J].J Transl Med,2019,17(1):202.
[10] Chen Q, Yin YJ, Chen WY, et al. Assessment of the association between serum uric acid levels and the incidence of hypertension in nonmetabolic syndrome subjects: A prospective observational study[J].Medicine (Baltimore),2018,97(6):e9765.
[11] Syamala S, Li J, Shankar A. Association between serum uric acid and prehypertension among US adults[J].J Hypertens,2007,25(8):1583-1589.
[12] 陈源源,王增武,李建军,等. 高血压患者血压血脂综合管理中国专家共识[J].中华高血压杂志,2019,27(7):605-614.
[13] Kuwabara M, Borghi C, Cicero A, et al. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan[J].Int J Cardiol,2018,261:183-188.
[14] Zhu Y, Hu Y, Huang T, et al. High uric acid directly inhibits insulin signalling and induces insulin resistance[J].Biochem Biophys Res Commun,2014,447(4):707-714.