|
|
|
| Perioperative Changes of T Cell Subsets in Patients with Intracranial Aneurysm Clipping |
| WANG Guo-yan, CHEN Zhi-biao |
| Department of Neurosurgery, Renmin Hospital of Wuhan University,Wuhan City, Hubei province 430060 |
|
|
|
|
Abstract 【Objective】To investigate the changes of T cell subsets in patients with intracranial aneurysm clipping during perioperative period. 【Methods】From January 2009 to January 2015, 80 patients with anterior circulation intracranial aneurysm occlusion in Wuhan University People's Hospital were selected as the study subjects (observation group), and 40 healthy persons in the same period were selected as the control group. The changes of CD3+, CD4+, CD8+ and CD4+/CD8+ T lymphocyte in peripheral blood of the two groups during the perioperative period were compared. 【Results】The number of CD3+, CD4+T, CD8+ lymphocyte and the ratio of CD4+/CD8+ in the observation group were not significantly different from those in the control group on the first day before operation (P>0.05); the number of CD3+, CD4+ T lymphocyte and the ratio of CD4+/CD8+ in the patients during operation and on the first day after operation were significantly lower than those on the first day before operation (P<0.05); the number of CD3+, CD4+T lymphocyte and the ratio of CD4+/CD8+ in the patients on the first day after operation were significantly lower than those on the first day before operation The number of CD8+ T lymphocyte was significantly lower than that during operation (P<0.05), but there was no significant change in the number of CD8+ T lymphocyte before and after operation (P>0.05). 【Conclusion】 In patients with intracranial aneurysm clamping, the cellular immune function during and after operation is low, and the cellular immune function after operation is lower than that during operation.
|
|
Received: 18 April 2018
|
|
|
|
|
|
[1] 刘骏辉, 陈谦学.颅内动脉瘤显微手术治疗临床分析[J].中国临床神经外科杂志, 2015,23(6):370-372.
[2] 王帅, 梁朝辉, 胡福广,等.两种入路行前交通动脉瘤夹闭手术的分析[J].脑与神经疾病杂志, 2017, 25(2):97-101.
[3] 贾永军, 徐广明.经不同入路行垂体瘤切除术的疗效分析[J].中国临床神经科学, 2015,55(2):192-195.
[4] 刘海玉, 周国平, 李东峰,等.内镜下经鼻蝶窦入路行脑垂体瘤切除术后并发颅内感染相关因素分析[J].中华医院感染学杂志, 2017, 27(3):605-608.
[5] 冯枫.不同浓度罗哌卡因用于上肢淋巴静脉吻合患者臂丛阻滞的效果分析[J].中国现代医学杂志, 2016, 26(11):117-121.
[6] Guberina N, Lechel U, Forsting M,et al.Dose comparison of classical 2-plane DSA and 3D rotational angiography for the assessment of intracranial aneurysms[J].Neuroradiology,2016, 58(7):1-6. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2010, 27(5): 965-966. |
|
|
|
|
2019, Vol. 36 
