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| Application of Phthalocyanine Green Fluorescence Staining Combined with Electrophysiological Monitoring in Glioblastoma Surgery in Brain Functional Area |
| ZHANG Jue, SHU Guo-wei, GONG Li,et al |
| Shanghai Shuguang Hospital,Shanghai 201203 |
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Abstract 【Objective】To investigate the application of phthalocyanine green fluorescence staining combined with electrophysiological monitoring in the treatment of glioma in brain functional area. 【Methods】A total of 105 patients with brain glandular gliomas admitted to our hospital from April 2012 to March 2018 were enrolled. Patients were divided into observation group (n=51) and control group (n=54) according to different detection methods.The patients in the observation group were treated with phthalocyanine green fluorescence staining combined with electrophysiological monitoring to guide glioma surgery. The patients in the control group were only treated with conventional craniotomy under electrophysiological monitoring. Observed the neurophysiological monitoring of the two groups, the surgical removal of the tumor and the recovery of the patient, the improvement of neurological function. The accuracy of the phthalocyanoma boundary was evaluated by analyzing the fluorescence of the indocyanine green. 【Results】Neuroelectrophysiological examination revealed that the tumor location of the patients was mainly in the linguistic area, limb movement area and sensory area. The total tumor resection rate was significantly higher in the observation group than in the control group (P<0.05). The recovery of muscle strength and KPS score in the observation group were significantly better than those in the control group (P<005). The recovery of neurological function in the exercise and sensory areas of the observation group was significantly better than that of the control group (P<0.05). The sensitivity of the observation group using phthalocyanine green fluorescent staining to evaluate the glioma cell border was 92.15% and the specificity was 90.19%.【Conclusion】The use of indocyanine green fluorescence staining combined with electrophysiological monitoring technology in patients with glioma of brain function area can guide the surgical removal of tumors, which can accurately identify tumor lesions and maximize the protection of patients' nerve function.
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Received: 11 January 2019
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[1] Tanigawa N, Matsumura M, Amaya H,et al. Tumor vascularity correlates with the prognosis of patients with esophageal squamous cell carcinoma[J].Cancer,2015,2:220-225.
[2] Burley TA, M czyńska J, Shah A, et al. Near-infrared photoimmunotherapy targeting EGFR - shedding new light on glioblastoma treatment[J].Int J Cancer,2018,11:2363-2374.
[3] 张玉海, 刘宏毅, 张锐,等. 多模态影像联合电生理监测在脑功能区胶质瘤手术中的应用研究[J].临床神经外科杂志,2016,13(5):335-339.
[4] 王伟, 廉海平, 王拓,等. 脑运动功能区病变患者术中采用神经电生理监测对其预后评估的作用[J].第三军医大学学报, 2017, 39(16):1664-1668.
[5] Woodward D E, Cook J, Tracqui P, et al. A mathematical model of glioma growth: the effect of extent of surgical resection[J].Cell Prolif,2017, 6:269-288.
[6] Saito T, Muragaki Y, Maruyama T, et al. Difficulty in identification of the frontal language area in patients with dominant frontal gliomas that involve the pars triangularis[J].J Neurosurg,2016,125(4):803-811.
[7] Glund S, Mattheus M, Runge F, et al. Relative bioavailability of an empagliflozin 25-mg/linagliptin 5-mg fixed-dose combination tablet[J].Int J Clin Pharmacol Ther,2017,55(4):355-367.
[8] Mansfield K E, Julius S, Jordan J L, et al. A systematic review and meta-analysis of the prevalence of chronic widespread pain in the general population[J].Pain,2016, 157(1):55-64. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(3): 615-617. |
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2019, Vol. 36 
