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| Expression and Clinical Significance of Cys-c, β2-microglobulin and RBP in Patients with Type 2 Diabetic Nephropathy |
| LIU Rong-zhi, RAN En-rong |
| Suining City Central Hospital, Sichuan Province 629000 |
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Abstract 【Objective】 To study the expression and clinical significance of Cys-c (cystatin C), β2-MG (β2-microglobulin) and RBP (retinol binding protein) in patients with type 2 diabetic nephropathy. 【Methods】Eighty-one patients with type 2 diabetic nephropathy were enrolled in this study. According to urinary albumin excretion rate (UAER), patients were divided into group A (30 cases), group B (24 cases) and group C (27 cases). In the same period, 26 healthy volunteers were enrolled as the control group. The levels of Cys-c, β2-microglobulin and RBP in the four groups of patients were recorded. ROC curve was used to analyze the sensitivity and specificity of serum Cys-c, β2-MG and RBP content in the diagnosis of type 2 diabetic nephropathy . 【Results】 The levels of Cys-c, β2-MG and RBP in the control group were not significantly different from those in group A (P>0.05). The levels of Cys-c, β2-MG and RBP in the control group and group A were significantly lower than those in group B and group C (P<0.05). The levels of Cys-c, β2-MG and RBP in group B were significantly lower than those of group C (P<0.05). 【Conclusion】 Cys-c, β2-microglobulin and RBP play an important role in the clinical diagnosis, treatment and disease monitoring of patients with type 2 diabetic nephropathy, all of which have high sensitivity and specificity.
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Received: 10 February 2018
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2019, Vol. 36 
