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| Correlation between Ambulatory Pulse Pressure Index and Flow-mediated Dilation in Patients with Type 2 Diabetes Mellitus and Hypertension |
| XU Dong, WU Qi-nan |
| Department of Endocrinology, Chenjiaqiao Hospital of Shapingba District, Chongqing Sichuan 401331 |
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Abstract 【Objective】To investigate the correlation between ambulatory pulse pressure index (APPI) and flow-mediated endothelium-dependent vasodilation(FMD)in patients with type 2 diabetes mellitus (T2DM) complicated with hypertension. 【Methods】Thirty patients with primary hypertension and 30 patients with primary hypertension and type 2 diabetes from January 2018 to October 2018 were enrolled for the study as hypertension group and hypertension combined with diabetes mellitus group, respectively. Further, 30 healthy adult volunteer who received physical examination in our hospital were selected as the control group. The results of blood pressure and FMD were compared among three groups, and Pearson correlation coefficient was performed to analyze the correlation of APPI and FMD. 【Results】 There were significant differences in SBP, DBP, 24h SBP, 24h DBP and APPI among three groups (P<0.05). The SBP and DBP in the hypertension combined with diabetes mellitus group and the hypertension group were significantly higher than those in the control group. The 24h SBP, 24h DBP and APPI in the hypertension combined with diabetes mellitus group were significantly higher than those in the hypertension group and the control group. The 24h DBP: and APPI in the hypertension group were significantly higher than those in the control group. There were significant differences in basic vascular diameter, maximum diameter after reactive congestion or nitroglycerin administration, and FMD among the three groups (P<0.05). The diameter of the vessel under the basal state and the maximum diameter of the blood vessel after reactive hyperemia or nitroglycerin in the hypertension combined with diabetes mellitus group were significantly higher than those in the hypertension group and the control group. The FMD in the hypertension combined with diabetes mellitus group was significantly lower than that of the hypertension group and the control group, and FMD in the hypertension group was significantly lower than that in the control group. FMD was negatively correlated with 24h SBP and APPI in all subjects (P<0.05). 【Conclusion】The APPI of T2DM patients with hypertension was significantly increased and FMD significantly decreased. There was a significant negative correlation between APPI and FMD.
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Received: 15 January 2019
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2019, Vol. 36 
