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| Clinical Study on the Effect of the Polymorphism of CACNA1C on Geriatric Hypertension Treatment with Nifedipine |
| WU Wei, PENG Qianwen |
| The First Hospital of Changsha, Hunan, Changsha,410000 |
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Abstract Objective To observe the effect of the polymorphism of CACNA1C on geriatric hypertension treatment with nifedipine. Methods CACNA1C genotyping (rs2222732,rs2239050,rs2239128 locus) was performed in 96 elderly patients with hypertension. Nifedipine 20 mg/d was given for 5 weeks. Fasting venous blood was collected before and after treatment. Fasting blood glucose(FPG), blood urea nitrogen(BUN), creatinine (Cr), systolic blood pressure (SBP), diastolic blood pressure (DBP) and body mass index (BMI) were measured. Results There was no significant difference in SBP, DBP, BMI,serum FPG, BUN, Cr level of between patients with different genotypes (rs2222732, rs2239050, rs2239128 locus) before and after treatment (P>0.05).The decrease of SBP,DBP in TT patients with rs2222732 locus was significantly higher than that in patients with TG, GG genotype before and after treatment (P<0.05).The decrease of SBP,DBP in rs2239050 genotype patients before and after treatment was significantly higher than that in GC, CC type patients (P<0.05).There was no significant difference in the decrease of SBP,DBP between groups before and after treatment in CT,TT, CC patients with rs2239128 locus (P>0.05).Conclusion The polymorphisms of rs2222732 and rs2239050 locus of CACNA1C gene have great influence on the antihypertensive effect of nifedipine.
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Received: 08 June 2018
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2019, Vol. 36 
