不同程度CHF患者血清炎症因子的变化及发病机制研究

doi:10.3969/j.issn.1671-7171.2019.11.002

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Abstract 【Objective】To explore the correlation between the activation of NOD-like-Receptor protein 3(NLRP3)inflammatory corpuscles and the classification of heart function in patients with chronic heart failure (CHF). 【Methods】From June 2017 to June 2018, 50 patients with CHF were enrolled in our hospital. NYHA heart function grading: 13 patients of grade Ⅱ, 23 patients of grade Ⅲ, 14 patients of grade Ⅳ; another 50 healthy people of our hospital at the same period were selected as the control group. The expression of NLRP3, IL-1 β (IL-1 β) and IL-18 (OD) in the two groups were measured by Western blot analysis, the levels of IL-1 β and IL-18 (PG/mL) were measured by enzyme-linked immunosorbent assay, and the left ventricular ejection fraction (LVEF) and left ventricular end diastolic diameter (LVEDd) were evaluated by echocardiography. 【Results】The OD value of NLRP3, IL-1 β and IL-18 protein expression in CHF group was higher than that in the control group (P<0.05). With the aggravation of heart function damage (Ⅱ ~ Ⅳ), the OD value of NLRP3, IL-1 β and IL-18 protein expression gradually increased, and the serum IL-1 β and IL-18 levels also gradually increased in all levels of the heart function groups, while the LVEF gradually decreased, and the LVEDd gradually increased, the difference was statistically significant (P<0.05). The expression of NLRP3, IL-1 β and IL-18 was positively correlated with cardiac function grade Ⅳ. 【Conclusion】The activation of NLRP3 inflammatory corpuscles may be involved in the pathogenesis of CHF and is closely related to the classification of cardiac function.

Key words： Heart Failure/PP Cytokines

Received: 21 October 2019

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R541.6

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2019.11.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2019/V36/I11/2084

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