|
|
|
| Changes of Serum TGF-β1,CTGF Levels and their Correlation with Cardiac Function in Elderly Patients with Hypertension and Chronic Heart Failure |
| ZHEN Hai-xu |
| The Fifth People's Hospital of Qinghai Province, Xining, Qinghai,810007,China |
|
|
|
|
Abstract 【Objective】 To investigate the changes of serum transforming growth factor-β1(TGF-β1) and connective tissue growth factor (CTGF) levels in elderly hypertensive patients with chronic heart failure (CHF) and their correlation with cardiac function. 【Methods】 The clinical data of 130 elderly patients with hypertension complicated with CHF from January 2018 to July 2018 were selected (observation group) and 60 elderly patients with simple hypertension were selected as control group. Serum TGF-β1,CTGF and cardiac function were compared between the two groups, and the correlation between serum TGF-β1,CTGF and cardiac function was analyzed by Pearson correlation. 【Results】 The left ventricular ejection fraction (LVEF) in the observation group was significantly lower than that in the control group, and the left ventricular mass index (LVMI) of left ventricular end-diastolic diameter (LVEDd) was significantly higher than that of the control group (P<0.05). The serum levels of TGF-β1, CTGF in the observation group were significantly higher than those in the control group (P<0.05). The serum levels of TGF-β1,CTGF in patients with NYHA grade Ⅱ, Ⅲ and Ⅳ increased with the increase of NYHA grade, and the difference between the two groups was statistically significant (P<0.05). There was a significant negative correlation between serum TGF-β1,CTGF and LVEF in hypertensive patients with CHD, and a positive correlation between serum TGF-β1,CTGF and LVMI (P<0.05).【Conclusion】 Serum TGF-β1 and CTGF are significantly increased in elderly patients with hypertension and chronic heart failure and are closely related to cardiac function and myocardial remodeling.
|
|
Received: 12 September 2018
|
|
|
|
|
|
[1] 邢文, 赵春梅, 王德国. 血清成纤维细胞生长因子23与慢性心力衰竭心室重构的相关性[J].临床心血管病杂志, 2016,18(1):36-39.
[2] 蒋洪强, 张金国, 谭洪勇,等. 黄芪甲苷对慢性心力衰竭大鼠心肌纤维化和结缔组织生长因子表达的影响[J].中国循环杂志, 2016, 31(2):165-169.
[3] 刘欣,康毅,贺慧杰,等. 糖尿病大鼠心肌TGF-β1 表达及细胞凋亡的实验研究[J].中国病理生理杂志, 2007, 23(2):303-306.
[4] 张志宏, 张丽华, 郑春霞,等. 应用半乳糖凝集素3及成纤维细胞生长因子23评估慢性肾脏病患者的心血管危险因素[J].肾脏病与透析肾移植杂志, 2016, 25(4):301-307.
[5] 沈丹萍, 戈东辉, 陈显达,等. bFGF通过促进心脏血管新生改善心肌梗死后小鼠心脏重构[J].中国病理生理杂志, 2018, 34(1):47-51.
[6] 姚志勇. 镉的生物毒性及对心肌细胞损伤机制的研究进展[J].国外医学(医学地理分册), 2013, 34(2): 133-136.
[7] Li G, Tang L, Jia P,et al.Elevated Plasma Connective tissue growth factor levels in children with pulmonary arterial hypertension associated with congenital heart disease[J].Pediatric Cardiol,2016, 37(4):714-721.
[8] 谢亚芹,李秀华. TGF-β1和CTGF与慢性心力衰竭心肌纤维化的关系[J].承德医学院学报, 2011, 28(2):181-183.
[9] Purohit T, He T, Qin Z, et al.Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging[J].J Dermatol Sci,2016, 83(1):80-83.
[10] 施鹏, 陶辉, 张家贵,等. 靶向沉默SIRT1对乳鼠心肌成纤维细胞增殖的影响[J].安徽医科大学学报, 2017, 52(4):471-475.
[11] 王擎, 张云雁, 王志农. 成纤维细胞在心房纤颤发生中的作用机制[J].医学研究生学报, 2016,19(2):214-217. |
|
|
|
2019, Vol. 36 
