Abstract 【Objective】To evaluate the association between retinol binding protein (RBP) and non-alcoholic fatty liver disease (NAFLD).【Methods】A document retrieval was conducted by retrieval systems,including PubMed,Web of Science,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI), CBM, VIP and Wan Fang Database, to collect the published papers of case-control studies on the theme of association between serum RBP and NAFLD up to Dec. 2017.Data collection and quality assessment were performed by two authors, respectively.All the meta-analysis were conducted with software RevMan 5.3.【Results】A total of 14 qualified studies were included in the meta-analysis.The analysis showed that serum RBP might be significantly higher in patients with NAFLD than non-NAFLD patients (SMD=0.96,95%CI:0.63~1.28,P<0.05)。Clinical subtype specific subgroup analysis showed that RBP might be higher in patients with type 2 diabetes mellitus and NAFLD than non-NAFLD patients (SMD=0.70,95%CI:0.42~0.97,P<0.001).Age specific subgroup analysis showed the RBP might be higher in patient aged ≥18y than the control (SMD=0.82,95%CI:0.55~1.09,P<0.001), while difference between patient and control aged <18y were insignificant (SMD=1.68,95%CI:-0.22~3.59,P=0.08). Sensitivity and publication bias analyses indicated that our results were stable and without obvious publication bias.【Conclusion】 The meta-analysis shows that serum RBP might be higher in patients aged ≥18y with NAFLD than non-NAFLD patients.
GUO Kuan-peng,ZHANG Lin,MO Li-ya, et al. Association between Retinol Binding Protein and Non-alcoholic Fatty Liver Disease: a Meta-analysis[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(10): 1873-1876.
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2018, Vol. 35 
