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| Levels of Peripheral Blood Treg Cells and NF-κB-p65 in Patients with Parkinson's Disease and their Clinical Significance |
| Wang Yachan, Chen Yufei, Wang Qiuju |
| The Ninth People's Hospital of Zhengzhou,Zhengzhou Henan 450000 |
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Abstract 【Objective】 To investigate the levels of peripheral blood Treg cells and nuclear factor-κB p65 (NF-κB-p65) and their clinical significance in patients with Parkinson's disease (PD). 【Methods】 A total of 82 PD patients admitted to the Ninth People's Hospital of Zhengzhou from April 2019 to July 2022 were enrolled and divided into good-prognosis group (n=57) and poor-prognosis group (n=25) according to their prognosis. Flow cytometry was used to detect the level of Treg cells, and reverse transcription-polymerase chain reaction (RT-PCR) was applied to detect NF-κB-p65 level. The prognostic influencing factors of PD patients were analyzed, and the predictive value of Treg cells and NF-κB-p65 for poor prognosis in PD patients was evaluated. 【Results】 The levels of hypoxia-inducible factor-1α (HIF-1α), interleukin-1β (IL-1β) and NF-κB-p65 in the poor-prognosis group were higher, while Treg cell level was lower than those in the good-prognosis group (all P<0.05). Binary Logistic regression analysis showed that HIF-1α, IL-1β and NF-κB-p65 were risk factors for poor prognosis in PD patients (all P<0.05), whereas Treg cell was a protective factor (P<0.05). Pearson correlation analysis demonstrated that poor prognosis of PD patients was positively correlated with HIF-1α, IL-1β and NF-κB-p65 (r=0.529, 0.537, 0.602, all P<0.05), and negatively correlated with Treg cells (r=-0.504, P<0.05). Receiver operating characteristic curve analysis indicated that the combined detection of HIF-1α, IL-1β, NF-κB-p65 and Treg cells possessed high predictive value for poor prognosis of PD patients (area under the curve＞0.9). 【Conclusion】 Low expression of peripheral blood Treg cells and over-expression of inflammatory factor NF-κB-p65 before treatment may suggest poor post-treatment prognosis in PD patients, which can serve as indicators for poor prognosis of PD patients.
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Received: 27 April 2025
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2026, Vol. 43 
