血清淀粉样蛋白A、前白蛋白在急性呼吸道感染患者治疗效果与预后评估中的应用价值

doi:10.3969/j.issn.1671-7171.2026.07.017

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1279 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】 To explore the application value of serum amyloid A (SAA) and prealbumin (PA) levels in evaluating therapeutic efficacy and prognosis of patients with acute respiratory infection (ARI). 【Methods】 A total of 500 patients with ARI treated in our hospital from February 2023 to February 2025 were retrospectively analyzed. According to pathogen test results, patients were divided into viral infection group (n=238) and bacterial infection group (n=262). Based on disease severity, they were classified into mild group (n=182), moderate group (n=149) and severe group (n=169). In accordance with clinical outcomes, patients were divided into good prognosis group (n=407) and poor prognosis group (n=93). The levels of SAA and PA in each group were detected and compared. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive efficiency of SAA and PA for the severity of ARI. Logistic regression analysis was adopted to identify influencing factors of poor prognosis in ARI patients. 【Results】 The level of SAA in bacterial infection group was higher than that of viral infection group, while PA level was lower, with statistically significant differences (P<0.05). As the severity of ARI aggravated, SAA level increased progressively and PA level decreased gradually, and intergroup differences were statistically significant (P<0.05). ROC curve analysis showed that combined detection of SAA and PA exhibited superior predictive efficiency for ARI severity compared with single indicator (P<0.05). The proportions of patients with bacterial infection, severe illness and lower respiratory tract infection were higher in poor prognosis group (P<0.05). Inflammatory indicators including SAA and white blood cell (WBC) count, C-reactive protein (CRP) were significantly higher, while PA was markedly lower in poor prognosis group (all P<0.05). Infection type, disease severity, infection site, SAA level, PA level, WBC count and CRP were independent influencing factors for poor prognosis of ARI patients. 【Conclusions】 The changes of serum SAA and PA levels possess important clinical value in judging therapeutic efficacy and predicting prognosis of patients with acute respiratory infection.

Key words： Respiratory Tract Infections Acute Disease Amyloid Prealbumin Prognosis

Received: 03 April 2026

PACS:

R563.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	FAN Linpeng
	LU Ling
	GUO Yunbo

Cite this article:

FAN Linpeng,LU Ling,GUO Yunbo. Application Value of Serum Amyloid A and Prealbumin in Evaluating Therapeutic Efficacy and Prognosis of Patients with Acute Respiratory Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1116-1119.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.07.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I7/1116

[1] 蔡霖,高晓曼,王子建,等.2023—2024年福建省10家区域性儿童医学中心儿童急性呼吸道感染非细菌性病原体分布及流行病学特征[J].中华医院感染学杂志,2026,36 (7):1-6.
[2] 刘伟峰,刘高峰,魏晓妲. 磷酸奥司他韦联合小儿豉翘清热颗粒治疗急性上呼吸道感染患儿的疗效[J].医学临床研究,2025,42(9):1670-1672.
[3] RECTOR A, BLOEMEN M, VAN RANST M, et al. Used paper tissues for pathogen identification in acute respiratory infection[J].J Med Virol, 2023, 95(10):e29127.
[4] 刘利,李颖,孙文白,等. 血清淀粉样蛋白A1通过抑制血小板反应蛋白4表达促进胰腺导管腺癌细胞的增殖和转移[J].中华实验外科杂志,2024,41(3):504-507.
[5] 缪枝彤,胡义玲,张乔乔. 儿童鼻病毒呼吸道感染特征及血清学指标与分子分型、重症肺炎关系[J].哈尔滨医科大学学报,2025,59(4):436-441.
[6] 邢文珂,孙香君,马冰新,等. 全身炎症聚合指数联合CURB-65评分对急诊重症肺炎患者预后的预测价值[J].保健医学研究与实践,2025,22(10):107-113.
[7] 全球华人临床微生物暨感染学会. 成人门急诊急性呼吸道感染诊治与防控专家共识[J].中华传染病杂志,2024,42(6):321-337.
[8] MILLAR E V, ROSSI S P, POLLETT S, et al. Impact of nonpharmaceutical interventions during the COVID-19 pandemic on medically attended acute respiratory infection: the US Naval Academy experience[J].Mil Med, 2023, 188(5-6):e953-e956.
[9] 王俭,胡林兵,罗宁,等. 儿童急性呼吸道感染者PA、PSP、CD64、sCD14-ST的变化及其诊断价值[J].海南医学,2024,35(5):694-698.
[10] 颜玉丹,李晓琴,郑小丹,等. 血清PA、SAA、IL-6检测在小儿急性上呼吸道感染诊断中的应用[J].分子诊断与治疗杂志,2023,15(10):1808-1811.
[11] 陶芸,王晓旭. 血清PCT、CRP、SAA、IL-6水平与AECOPD患者合并呼吸道感染的相关性分析[J].医学临床研究,2023,40(4):564-567.
[12] GHIMIRE P, GACHHADAR R, PIYA N, et al. Prevalence and factors associated with acute respiratory infection among under-five children in selected tertiary hospitals of Kathmandu Valley[J].PLoS One, 2022, 17(4):e0265933.
[13] 王俭,万光平,李益,等. 小儿急性呼吸道感染PA、SAA、CD64、sCD14-ST水平及其诊断价值[J].中华医院感染学杂志,2023,33(23):3659-3663.
[14] 孙潇君,常晓艳,王艳坤,等. 儿童急性呼吸道感染流行病学及外周血PA、SAA、CRP和PCT变化[J].中华医院感染学杂志,2025,35(5):708-712.
[15] 董明星,韩宏武,王喜霞,等. 2022年1—12月咸阳市某儿童医院住院儿童肺炎链球菌感染的流行病学及临床特点[J].山东医药,2023,63(27):73-75.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(7): 1166-1169.