高频超声检查联合TSH检测在甲状腺癌诊断及其临床病理特征分析中的应用价值

doi:10.3969/j.issn.1671-7171.2026.05.013

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Abstract 【Objective】 To explore the application value of high-frequency ultrasonography combined with thyroid-stimulating hormone (TSH) detection in the diagnosis of thyroid carcinoma and the analysis of its clinicopathological characteristics. 【Methods】 The clinical data of 90 patients with thyroid carcinoma (observation group) admitted to The First People's Hospital of Zhengzhou from January 2022 to December 2024 were retrospectively analyzed, and the clinical data of 90 patients with thyroiditis admitted during the same period were selected as the control group. All patients underwent high-frequency ultrasonography and serum TSH detection. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of combined high-frequency ultrasonography and TSH detection for thyroid carcinoma. Spearman correlation analysis was adopted to explore the correlations of high-frequency ultrasonic features and TSH levels with clinicopathological characteristics of thyroid carcinoma patients. 【Results】 There was no significant difference in the proportion of internal hypoechogenicity between the two groups (P>0.05). The proportions of microcalcification, irregular boundary, blood flow grade 2-3 and TSH level in the observation group were higher than those in the control group, while the proportions of peripheral anechoic area and blood flow grade 0-1 were lower than those in the control group (P<0.05). The sensitivity, specificity and area under the curve (AUC) of combined high-frequency ultrasonography and TSH detection in diagnosing thyroid carcinoma were 96.7%, 97.8% and 0.963 respectively, showing higher diagnostic efficacy than single high-frequency ultrasonography or single TSH detection. Spearman correlation analysis showed that tumor diameter, lymph node metastasis, clinical stage, tumor differentiation degree and extrathyroidal invasion were positively correlated with internal hypoechogenicity, irregular boundary, blood flow grade and TSH level (P<0.05); tumor diameter and lymph node metastasis were positively correlated with microcalcification and peripheral anechoic area (P<0.05); clinical stage, tumor differentiation degree were negatively correlated with microcalcification and peripheral anechoic area (P<0.05);extracellular infiltration is negatively correlated with microcalcification foci. 【Conclusion】 High-frequency ultrasonography combined with TSH detection has high diagnostic value for thyroid carcinoma. Ultrasonic features and TSH levels are significantly correlated with clinicopathological characteristics such as tumor diameter, lymph node metastasis and clinical stage, which can provide reference for the diagnosis and condition evaluation of thyroid carcinoma.

Key words： Thyroid Neoplasms Ultrasonography Thyrotropin Diagnosis Pathological Conditions, Signs and Symptoms

Received: 06 August 2025

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R736.1

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	Articles by authors
	WANG Shaobo
	CHEN Yijie
	HU Yongbo

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WANG Shaobo,CHEN Yijie,HU Yongbo. Application Value of High-Frequency Ultrasonography Combined with TSH Detection in the Diagnosis of Thyroid Carcinoma and Analysis of its Clinicopathological Characteristics[J]. JOURNAL OF CLINICAL RESEARCH, 2026, 43(5): 750-753.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2026.05.013 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2026/V43/I5/750

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