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| Application of Serum Tumor Markers Combined with Narrow-Band Imaging-Magnifying Endoscopy in the Differential Diagnosis of Benign and Malignant Early Gastrointestinal Tumors |
| SONG Yanhua, WANG Jianfeng |
| Department of Endoscopic Diagnosis and Treatment, Nanyang Central Hospital,Nanyang Henan 473001 |
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Abstract 【Objective】 To investigate the value of serum tumor markers combined with narrow-band imaging-magnifying endoscopy (NBI-ME) in differentiating benign and malignant early gastrointestinal tumors. 【Methods】 A total of 216 patients who underwent endoscopic examination and treatment were enrolled. According to postoperative pathological results, 104 patients with malignant gastrointestinal tumors were assigned to the observation group, and 112 patients with benign lesions were assigned to the control group. General clinical data, serum tumor markers [carcinoembryonic antigen (CEA), tumor-specific growth factor (TSGF), carbohydrate antigen 19-9 (CA19-9), and alpha-fetoprotein (AFP)], and NBI-ME features were compared between the two groups. The lesion characteristics and diagnostic accuracy obtained by conventional white-light endoscopy and NBI-ME were compared. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the relevant indicators. 【Results】 Serum levels of CEA, TSGF, CA19-9, and AFP in the observation group were significantly higher than those in the control group. The proportions of discontinuous lesion borders, irregular surface microstructures, and irregular microvascular patterns in tumor tissues were significantly higher in the observation group than in the control group (P<0.05). The NBI-ME image scores were significantly higher than those of conventional white-light endoscopy (P<0.05). ROC analysis showed that the combination of serum tumor markers and NBI-ME had the highest diagnostic efficacy, with the accuracy, sensitivity, and specificity of 94.44%, 95.19%, and 93.75%, respectively. 【Conclusion】 The combined use of serum tumor markers and NBI-ME demonstrates a high positive detection rate in patients with early gastrointestinal tumors and it is worthy of clinical application.
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Received: 01 December 2025
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2026, Vol. 43 
