|
|
|
| Clinical Value of Serum 1,25(OH)2D3 Combined with 4-HNE, YKL-40 and sTREM-1 in the Diagnosis of Refractory Mycoplasma Pneumoniae Pneumonia in Children |
| WANG Zhe, ZHU Yunqi, WANG Siying, ZHU Yaqin, LIU Shan, ZOU Chaoxiong |
| Shuangfeng County People's Hospital, Shuangfeng Hunan 417700 |
|
|
|
|
Abstract 【Objective】 To explore the clinical value of serum 1,25-dihydroxyvitamin D3[1,25(OH)2D3] combined with 4-hydroxynonenal(4-HNE), human cartilage glycoprotein-39(YKL-40) and soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in the diagnosis of refractory Mycoplasma pneumoniae pneumonia(RMPP) in children. 【Methods】 A total of 50 children with RMPP(RMPP group) and 50 children with general Mycoplasma pneumoniae pneumonia(GMPP group) admitted to our hospital from December 2024 to June 2025 were selected, and 50 healthy children who underwent physical examination during the same period were selected as the control group. The serum levels of 1,25(OH)2D3, 4-HNE, YKL-40 and sTREM-1 were compared among the three groups. Pearson correlation analysis was used to analyze the correlation between serum 1,25(OH)2D3 and 4-HNE, YKL-40, sTREM-1. Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of serum 1,25(OH)2D3 combined with 4-HNE, YKL-40 and sTREM-1 levels for RMPP. 【Results】 There were statistically significant differences in serum levels of 1,25(OH)2D3, 4-HNE, YKL-40 and sTREM-1 among the three groups(P<0.05). The serum level of 1,25(OH)2D3 in the RMPP group was lower than that in the GMPP group and the control group, while the serum levels of 4-HNE, YKL-40 and sTREM-1 were higher than those in the GMPP group and the control group, with statistically significant differences(P<0.05). The serum level of 1,25(OH)2D3 in the GMPP group was lower than that in the control group, while the serum levels of 4-HNE, YKL-40 and sTREM-1 were higher than those in the control group, with statistically significant differences(P<0.05). Pearson correlation analysis showed that serum 1,25(OH)2D3 was negatively correlated with 4-HNE, YKL-40 and sTREM-1(r=－0.652, －0.713, －0.785, all P<0.05). ROC curve analysis showed that the area under the curve(AUC) of serum 1,25(OH)2D3 combined with 4-HNE, YKL-40 and sTREM-1 in the diagnosis of RMPP was 0.925, which was better than that of each index alone(P<0.05). 【Conclusion】 Serum 1,25(OH)2D3, 4-HNE, YKL-40 and sTREM-1 are correlated with the condition and prognosis of RMPP in children, and can be used as predictive indicators for clinical diagnosis and prognosis evaluation.
|
|
Received: 28 August 2025
|
|
|
|
|
|
[1] 李洁,马洋,尹君平,等.肺炎支原体耐药和儿童难治性肺炎支原体肺炎的关系研究[J].华北理工大学学报(医学版),2024,26(4):279-282.
[2] LU W H, WU X T, XU Y L, et al. Correction: Predictive value of bronchoscopy combined with CT score for refractory mycoplasma pneumoniae pneumonia in children [J].BMC Pulm Med,2024, 24(1):350.
[3] 夏煜,孙瑶,洪秀英,等.1,25-(OH)2D3在不同类型支原体肺炎中的表达差异及相关性分析[J].药物生物技术,2022,29(6):585-589.
[4] 付君静,李闯,陈胜阳.老年重症肺炎患者血清4-HNE、APC、sCD163预测预后不良的价值[J].海南医学,2024,35(11):1633-1638.
[5] 申琰军,刘秀莉,王菲.血清25羟维生素D、甲壳质酶蛋白40水平对儿童难治性支原体肺炎的诊断价值[J].中国医刊,2022,57(8):880-883.
[6] 祁莹祥,袁超.四种生物标志物联合检测对儿童难治性肺炎支原体肺炎的早期预测价值[J].金华职业技术学院学报,2024,24(3):65-69.
[7] LI M, WEI X, ZHANG S S, et al. Recognition of refractory Mycoplasma pneumoniae pneumonia among Myocoplasma pneumoniae pneumonia in hospitalized children: development and validation of a predictive nomogram model[J].BMC Pulm Med,2023, 23(1):383.
[8] 谢利娜,冯特,张万存,等.外周血细胞参数检测对儿童难治性肺炎支原体肺炎的诊断价值[J].医药论坛杂志,2024,45(6):578-582.
[9] 王娟,申翠平.外周血NLR、PLR、MPVLR联合CRP在儿童难治性肺炎支原体肺炎中的预测价值[J].检验医学与临床,2024,21(11):1631-1635.
[10] 徐丹, 章爱莲, 郑吉善, 等. 儿童难治性肺炎支原体肺炎早期识别的多中心前瞻性研究[J].中华儿科杂志, 2024,62(4):317-322.
[11] WU H, PAN J Q. Correlation between serum 4-HNE and lactic acid levels and disease status in patients with severe pneumonia and its diagnostic value and prognostic evaluation[J].Am J Transl Res,2023, 15(3):1913-1920.
[12] 黄光举,张慧玉,李娟,等.低剂量CT联合APOC1、YKL-40在儿童难治性支原体肺炎诊断中的应用[J].甘肃科技纵横,2022,51(8):84-87. |
|
|
|
2026, Vol. 43 
