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| Diagnostic Value of Combined Detection of Serum H-FABP and NT-proBNP in Congenital Heart Disease Complicated with Pulmonary Hypertension |
| ZHOU Wei, SHI Lei |
| Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203 |
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Abstract 【Objective】 To explore the diagnostic value of serum heart-type fatty acid-binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with congenital heart disease (CHD) complicated with pulmonary hypertension (PH). 【Methods】 A total of 86 patients with CHD were divided into the PH group (n=61) and the non-PH group (n=25) according to the presence or absence of complicated PH. The serum levels of H-FABP and NT-proBNP, as well as pulmonary artery diameter, pulmonary venous blood flow velocity, and pulmonary artery systolic pressure (PASP) were compared between the two groups. Pearson correlation analysis was used to explore the correlations of serum H-FABP and NT-proBNP with pulmonary artery diameter, pulmonary venous blood flow velocity, and PASP, and to evaluate the diagnostic efficacy of these indicators for PH in CHD patients. 【Results】The serum levels of H-FABP, NT-proBNP, blood flow velocity, and PASP in the PH group were significantly higher than those in the non-PH group, and the pulmonary artery diameter in the PH group was significantly larger than that in the non-PH group (all P<0.05). Serum H-FABP and NT-proBNP were positively correlated with pulmonary artery diameter, blood flow velocity, and PASP (all P<0.05). The accuracy of combined detection of H-FABP and NT-proBNP for predicting PH in CHD patients was 95.6%. 【Conclusion】 The serum levels of H-FABP and NT-proBNP are relatively high in CHD patients complicated with PH, and the combined detection of these two indicators has good efficacy for the diagnosis of CHD complicated with PH.
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Received: 25 October 2023
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2025, Vol. 42 
