血液透析联合血液灌流对慢性肾衰竭尿毒症患者微炎症状态及CVC发生的影响

doi:10.3969/j.issn.1671-7171.2025.11.013

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Abstract 【Objective】 To investigate the effect of hemodialysis (HD) combined with hemoperfusion on microinflammatory state–related markers and the risk of cardiac valve calcification (CVC) in patients with chronic renal failure and uremia.【Methods】 A total of 156 patients with chronic renal failure and uremia were randomly divided into a control group (the HD alone) and an observation group (the HD combined with hemoperfusion), with 78 cases in each group. Levels of microinflammatory markers [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6),interleukin-10(IL-10), and high-sensitivity C-reactive protein (hs-CRP)], blood urea nitrogen (BUN), serum creatinine (SCr), β2-microglobulin (β2-MG), parathyroid hormone (PTH), serum potassium (K⁺), serum calcium (Ca²⁺), endothelin (ET), and angiotensin Ⅱ (AngⅡ) were compared between the two groups before treatment and 3 months after treatment. The incidence of CVC during blood purification was also compared.【Results】 After treatment, levels of IL-6, IL-10, TNF-α, hs-CRP, BUN, SCr, β2-MG, PTH, K⁺, ET, and AngⅡ decreased significantly in both groups compared with baseline of pre-treatment (P<0.05), with the observation group showing lower levels than the control group (P<0.05). Ca²⁺ levels increased significantly in both groups after treatment (P<0.05), and the Ca²⁺ level in the observation group was higher than that in the control group (P<0.05). There was no significant difference in the incidence of CVC between the two groups after treatment (P>0.05).【Conclusion】 HD combined with hemoperfusion can suppress microinflammatory responses, regulate calcium, phosphorus, and potassium metabolism abnormalities, and alleviate vascular endothelial dysfunction in patients with chronic renal failure and uremia. However, it has no significant effect on the occurrence of CVC.

Key words： Kidney Failure, Chronic Uremia Renal Dialysis Hemoperfusion

Received: 31 August 2023

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R692.5

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	Articles by authors
	MA Shijing
	WEI Qichao
	WU Wenli
	et al

Cite this article:

MA Shijing,WEI Qichao,WU Wenli, et al. Effect of Hemodialysis Combined with Hemoperfusion on Microinflammatory State and the Occurrence of Cardiac Valve Calcification in Patients with Chronic Renal Failure and Uremia[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(11): 1887-1890.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.11.013 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I11/1887

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