常规平衡型全营养素制剂联合乳清蛋白强化营养支持对重型颅脑损伤患者营养状态及机体免疫的影响

doi:10.3969/j.issn.1671-7171.2025.10.014

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Abstract 【Objective】To explore the effect of routine balanced total nutrient preparation combined with whey protein-enhanced nutritional support on the nutritional status and immune function of patients with severe traumatic brain injury (STBI). 【Methods】The clinical data of 90 STBI patients receiving nasogastric feeding in our hospital from May 2021 to June 2024 were retrospectively analyzed. They were divided into the enhanced group (n=46) and the routine group (n=44) according to different nutritional support methods. The routine group was given nutritional support with routine balanced total nutrient preparation, while the enhanced group was given nutritional support with routine balanced total nutrient preparation combined with whey protein enhancement. Before and after intervention, the nutritional status [Mini Nutritional Assessment (MNA) score], serum nutritional indicators [total protein (TP), prealbumin (PA), albumin (Alb)], immune indicators [immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG)], prognosis and incidence of adverse reactions were compared between the two groups.【Results】After intervention, the MNA scores of both groups were higher than those before intervention, and the enhanced group was higher than the routine group, with a statistically significant difference (P<0.05). After intervention, the levels of TP, PA and Alb in both groups were higher than those before intervention, and the enhanced group was higher than the routine group, with statistically significant differences (P<0.05). After intervention, the levels of IgA, IgM and IgG in the enhanced group were higher than those in the routine group, with statistically significant differences (P<0.05). The length of hospital stay in the enhanced group was shorter than that in the routine group, with a statistically significant difference (P<0.05); after intervention, the National Institutes of Health Stroke Scale (NIHSS) score of the enhanced group was lower than that of the routine group, and the Activity of Daily Living (ADL) score was higher than that of the routine group, with statistically significant differences (P<0.05). The incidence of adverse reactions in the enhanced group and the routine group was 32.61% (15/46) and 38.64% (17/44) respectively, with no statistically significant difference (P>0.05).【Conclusion】Routine balanced total nutrient preparation combined with whey protein-enhanced nutritional support can improve the nutritional status of STBI patients, enhance immune function, promote the recovery of neurological function, improve the ability of daily living, and has good safety.

Key words： Craniocerebral Trauma Nutritional Support Lactalbumin Nutritional Status Immunity

Received: 09 December 2024

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R651.15

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	JIANG Jingfeng
	LIU Manman
	ZHAO Hongwu

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JIANG Jingfeng,LIU Manman,ZHAO Hongwu. Effect of Routine Balanced Total Nutrient Preparation Combined with Whey Protein-Enhanced Nutritional Support on Nutritional Status and Immune Function in Patients with Severe Traumatic Brain Injury[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(10): 1728-1731.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.10.014 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I10/1728

[1] XING X, JIANG R L, LEI S, et al. Electroacupuncture in treatment of acute gastrointestinal injury in patients with severe traumatic brain injury: a multicenter randomized controlled trial[J].Chin J Integr Med,2023,29(8):721-729.
[2] RAHIMIBASHAR F, FETRAT M K, GOHARI-MOGHADAM K, et al. The protective role of nutraceuticals in critically ill patients with traumatic brain injury[J].Adv Exp Med Biol,2021,1328:243-253.
[3] 郑亚东,李家兰,高英,等. 不同时机营养支持对重型颅脑损伤患者营养状态、免疫功能及临床预后的影响[J].重庆医学,2022,51(10):1691-1695.
[4] 张胜利,开标,陈昕. 不同营养支持方案对老年感染性休克患者肠道菌群、免疫功能以及炎症因子水平的影响[J].中国医刊,2023,58(9):974-977.
[5] 李晨翠,王晓静,林先萍,等. 含水解乳清蛋白肠内营养制剂联合脂肪乳氨基酸葡萄糖肠外营养对胃癌腹腔灌注化疗患者营养指标的影响[J].临床和实验医学杂志,2023,22(6):616-620.
[6] 岳向峰,张献娜,王雨,等. 营养风险筛查(NRS 2002-01.017)、营养不良诊断(GLIM-表现型指标01.028、病因型指标01.029)[J].中华临床营养杂志,2021,29(2):123-128.
[7] 邓瑛瑛,任英,王为杰,等. 危重患者能量和蛋白质摄入目标及计算方法最佳证据总结[J].中华危重病急救医学,2023,35(8):849-855.
[8] 郭文超,秦寒枝,滕娇,等. 成人重型颅脑损伤患者肠内营养支持的最佳证据总结[J].中国全科医学,2022,25(15):1825-1832.
[9] 孙海岚,许红霞,蒋宝泉.乳清蛋白与水解乳清蛋白的研究进展与临床应用现状[J].检验医学与临床,2014,11(23):3364-3366.
[10] 李云亮,刘晓霜,徐雅宣,等.乳清蛋白在临床肠内营养中的应用进展[J].中国乳品工业,2023,51(7):45-51.
[11] 李云亮,刘晓霜,徐雅宣,等.乳清蛋白及其活性肽在临床营养支持治疗中的应用[J].中国乳品工业,2022,50(11):34-39.
[12] ZHAO C,ASHAOLU T J.Bioactivity and safety of whey peptides[J].LWT,2020,134:109935.
[13] 陈瑞,蒲婷婷. 乳清蛋白联合肠内营养制剂对头颈部肿瘤放疗患者营养状态和耐受性的影响[J].中华实验外科杂志,2023,40(10):2089.
[14] 毛鸿晓,蒋和娣,李有政,等. 水解乳清蛋白在脑出血术后合并低蛋白血症病人肠内营养管理中的应用[J].护理研究,2022,36(5):938-940.
[15] 王艳莉,冯晔,周秀耕,等. 33例食管癌患者围术期补充乳清蛋白粉对术后并发症的预防作用[J].山东大学学报(医学版),2022,60(3):64-70.
[16] 田雪娜,孔唯唯,孙津,等. 乳清蛋白联合酪蛋白磷酸肽对环磷酰胺致免疫抑制小鼠的保护作用[J].食品研究与开发,2022,43(24):27-33.

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