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| The Impact of Olanzapine Combined with Cognitive Behavioral Therapy on Quality of Life and Clinical Efficacy in Patients with Schizophrenia |
| XU Xiaorong, ZHANG Jiaojiao, XIA Tingting |
| Department of Psychiatry, Rugao Mental Disease Prevention and Treatment Hospital, Rugao Jiangsu 226500 |
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Abstract 【Objective】 To explore the impact of olanzapine combined with cognitive behavioral therapy(CBT) on the quality of life and clinical efficacy in patients with schizophrenia.【Methods】 A total of 106 patients with schizophrenia admitted to our hospital from January 2023 to January 2025 were selected. According to different treatment methods, they were divided into the observation group(olanzapine combined with CBT) and the control group(olanzapine alone), with 53 cases in each group. Both groups received treatment for 12 weeks. The personality traits and psychological status [Minnesota Multiphasic Personality Inventory(MMPI) scores], rehabilitation efficacy [Inpatient Psychiatric Rehabilitation Outcome Scale(IPROS) scores], quality of life [World Health Organization Quality of Life-Brief Version(WHOQOL-BREF) scores], and symptom improvement [Positive and Negative Syndrome Scale(PANSS) scores] were compared between the two groups before and after treatment.【Results】 After treatment, the scores of negative symptoms, general symptoms, and positive symptoms in both groups were lower than those before treatment; the scores of negative symptoms and general symptoms in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the scores of work therapy, life ability, social ability, care and interest, and hygiene ability in both groups were lower than those before treatment; the scores in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the MMPI scores of both groups were lower than those before treatment; the score in the observation group was lower than that in the control group, with a statistically significant difference(P<0.05). After treatment, the scores of physical health, social relations, environmental dimension, and mental health in both groups were higher than those before treatment; the scores in the observation group were higher than those in the control group, with statistically significant differences(P<0.05).【Conclusion】 Olanzapine combined with CBT has a significant effect on relieving negative symptoms and general symptoms of schizophrenia patients, achieves good rehabilitation efficacy, can improve patients' personality traits and psychological status, and enhance their quality of life.
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Received: 05 March 2025
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[1] 杜恬恬,梁学军,史振娟,等.改良电休克联合高频rTMS在精神分裂症患者中的应用效果及对患者认知功能的影响[J].医学临床研究,2024,41(4):469-499.
[2] 张灵慧,陈宇斌,周郁秋,等. 治疗依从性问卷在精神分裂症患者中的信效度及测量等值性检验[J].军事护理,2025,42(1):50-54.
[3] 金志兴,赵静,朱殿明,等. 奥氮平联合越鞠丸治疗以阴性症状为主的精神分裂症的疗效[J].川北医学院学报,2024,39(12):1655-1658.
[4] 李瑞,程万良,蔡菡,等. 团体认知行为治疗对不同住院时长的男性慢性精神分裂症患者的效果[J].国际精神病学杂志,2023,50(5):987-989.
[5] GAEBEL W,STRICKER J,KERST A.Changes from ICD-10 to ICD-11 and future directions in psychiatric classification[J].Dialogues Clin Neurosci,2020,22(1):7-15.
[6] 孙焱,吴燕筱,王志忠. 中国西部某省社区精神分裂症患者药物治疗现状[J].中国心理卫生杂志,2020,34(6):516-522.
[7] 张春熙,任晓晖,杨先梅,等. 城乡精神分裂症患者生活质量及其影响因素研究[J].四川大学学报(医学版),2023,54(3):608.
[8] 宋籽良,宋清海,郑昌江. 奥氮平联合焦点解决式健康指导对精神分裂症患者病情及社会认知的影响[J].广东医学,2019,40(11):1608-1612.
[9] 陶敏,杨培锋. 氯氮平联合阿立哌唑在精神分裂症患者中的应用效果[J].中国当代医药,2022,29(31):102-104.
[10] 郭志华,李占江,马云,等. 短程认知行为治疗联合常规治疗对社区精神分裂症患者疗效的初步观察[J].中华精神科杂志,2015,48(6):331-338.
[11] 孙倩,杨晓婕,马云,等. 短程认知行为治疗改善精神分裂症患者生活质量的效果及影响因素[J].四川精神卫生,2024,37(3):219-225.
[12] 牛丹丹,陈玉明,庄晓伟,等. 基于认知行为治疗理论的在线随访干预对社区精神分裂症患者的康复效果[J].中国康复,2023,38(2):124-128.
[13] 梁忠新,秦轶灵,严文琼,等. 认知行为治疗联合阿立哌唑对慢性精神分裂症患者自知力的影响[J].中国医药科学,2019,9(23):286-288.
[14] 吕明维,黄境良,刘晓强. 阿立哌唑联合认知行为疗法治疗精神分裂症的效果观察[J].中国民康医学,2019,31(21):109-111. |
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2025, Vol. 42 
