瘦素、胰高血糖素在结直肠癌组织中的表达水平及其意义<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.09.002

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Abstract 【Objective】 To investigate the expression levels of leptin(LEP) and glucagon(GCG) in colorectal cancer(CRC) tissues and their clinical significance.【Methods】 Tissue samples of CRC were collected from 34 patients who underwent surgical treatment in our hospital from January 2023 to January 2024. The expression levels of LEP and GCG were detected, and their correlations with the clinicopathological features of CRC patients were analyzed.【Results】 Among the 34 CRC patients, the age ranged from 44 to 80 years, with an average of(66.82±12.36) years; 58.82%(20/34) were male; the prevalence of diabetes was 52.94%(18/34); the body mass index(BMI) ranged from 19.6 to 37.3 kg/m², with an average of(24.86±3.88) kg/m². Among them, 35.29%(12/34) were overweight(23.5 kg/m²≤BMI<25.0 kg/m²) and 11.76%(4/34) were obese(BMI≥25.0 kg/m²). Immunohistochemical analysis showed that the positive expression of LEP in CRC tissues was correlated with tumor diameter(P=0.014), differentiation grade(P=0.012), TNM stage(P=0.014) and the presence of diabetes(P=0.023), while the positive expression of LEP in paracancerous tissues of CRC had no correlation with clinicopathological features(P>0.05). GCG showed characteristic deletion in CRC tissues, and there was a significant difference in the expression of GCG in paracancerous tissues between patients with stage Ⅰ/Ⅱ and stage Ⅲ/Ⅳ(P<0.05).【Conclusion】 The expression of LEP in CRC tissues and the expression of GCG in paracancerous tissues are significantly correlated with tumor progression and metabolic characteristics, which provides a new direction for the targeted therapy of metabolism-related CRC.

Key words： Diabetes Mellitus Colorectal Neoplasms Obesity Leptin Glucagon

Received: 13 June 2025

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R735.35

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.09.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I9/1493

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