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| Effect of Bevacizumab Combined with Neoadjuvant Chemotherapy on Tumor Marker Levels and Prognosis in Patients with Locally Advanced Cervical Cancer |
| KANG Hongmei, GAO Dongmei, WANG Feipeng, et al |
| Department of Family Planning Service, Maternal and Child Health Hospital of Yulin District, Yulin Shaanxi 719000 |
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Abstract 【Objective】 To investigate the effect of bevacizumab combined with neoadjuvant chemotherapy on tumor marker levels and prognosis in patients with locally advanced cervical cancer.【Methods】 A total of 98 patients with locally advanced cervical cancer were randomly divided into the observation group and the control group, with 49 cases in each group. The control group was treated with a neoadjuvant chemotherapy regimen, while the observation group received bevacizumab in addition to the same chemotherapy regimen as control. Clinical efficacy, levels of T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+), serum tumor markers [squamous cell carcinoma antigen (SCC), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA)], incidence of adverse reactions, and 1-year survival were compared between the two groups.【Results】 The objective response rate (ORR) and disease control rate (DCR) in the observation group were significantly higher than those in the control group (P<0.05). After treatment, the levels of CD4+ and CD4+/CD8+ increased, while CD8+ levels decreased in both groups (P<0.05); moreover, the observation group showed higher CD4+ and CD4+/CD8+ levels and lower CD8+ levels compared with the control group (P<0.05). After treatment, serum levels of CEA, CA125, and SCC in both control and observation groups were significantly lower than those before treatment (P<0.05), with the observation group showing significantly lower levels than the control group (P<0.05). There was no significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). Both groups were followed up for 1 year postoperatively, and Kaplan-Meier survival analysis showed no statistically significant difference in survival rate between the two groups (Log-Rank=1.800, P=0.180).【Conclusion】 Bevacizumab combined with neoadjuvant chemotherapy can effectively improve clinical symptoms and reduce tumor marker levels in patients with locally advanced cervical cancer.
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Received: 20 November 2023
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2025, Vol. 42 
