3.0T磁共振Histo技术和多回波Dixon技术在定量分析肥胖儿童非酒精性脂肪肝病中的应用价值<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.05.002

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Abstract 【Objective】To explore the application value of 3.0T magnetic resonance Histo technology and multi-echo Dixon technology in the quantitative analysis of non-alcoholic fatty liver disease(NAFLD) in obese children. 【Methods】 A total of 137 children aged 7 to 15 years who were diagnosed as obese in the Department of Child Health Care of our hospital from December 2021 to December 2023 were prospectively selected, and 40 non-obese healthy children of the same age group who underwent physical examinations in our hospital during the same period (the healthy control group) were selected. According to the diagnosis and treatment guidelines for non-alcoholic fatty liver disease, obese children were divided into the simple obesity group (n=45), the NAFLD group (n=42), and the non-alcoholic steatohepatitis group (NASH group, n=50). All the research subjects underwent 3.0T magnetic resonance Histo and multi-echo Dixon technique examinations. The magnetic resonance spectroscopy-proton density fat fraction (MRS-PDFF) and magnetic resonance-proton density fat fraction (MRI-PDFF) of different groups were compared. 【Results】The MRS-PDFF and MRI-PDFF in the simple obesity group, NAFLD group and the NASH group showed an increasing trend. Comparisons among the groups showed statistically significant differences (P<0.05). The MRS-PDFF and MRI-PDFF in the simple obesity group, the NAFLD group and the NASH group were significantly higher than those in the healthy control group. The differences were all statistically significant (P<0.05). Pearson correlation analysis showed that MRS-PDFF was significantly correlated with MRI-PDFF in the healthy control group, the simple obesity group, the NAFLD group, and the NASH group (P<0.05). Spearman correlation analysis showed that there was no significant correlation between MRS-PDFFF and MRI-PDF in obese children and BMI or waist circumference/height (all P>0.05). 【Conclusion】 The 3.0T magnetic resonance Histo technique and the multi-echo Dixon technique can quantitatively assess the fat content of the liver more accurately, identify the fat infiltration of the liver at an early stage, and distinguish the degree of liver fat infiltration in different obese children.

Key words： Non-alcoholic Fatty Liver Disease Pediatric Obesity Magnetic Resonance Imaging Diagnosis

Received: 15 May 2024

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R725.75

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	TANG Jing
	LI Chunwang
	CAI Qifang
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TANG Jing,LI Chunwang,CAI Qifang, et al. The Application Value of 3.0T Magnetic Resonance Histo Technology and Multi-Echo Dixon Technology in the Quantitative Analysis of Non-Alcoholic Fatty Liver Disease in Obese Children[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(5): 740-743.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.05.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I5/740

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