Abstract 【Objective】To investigate the association between early blood inflammatory markers and the severity of disease in patients with community-acquired pneumonia (CAP). 【Methods】A total of 99 patients with CAP treated in our hospital from November 2022 to May 2024 were selected and divided into mild group, moderate group and severe group according to the pneumonia Severity index (PSI) score. Laboratory detection indicators and early blood inflammation indicators of patients were collected, and Pearson was used to analyze the correlation between early blood inflammation indicators and the severity of disease in CAP patients. 【Results】There were 33 cases (33.33%) in the mild group, 35 cases (35.36%) in the moderate group, and 31 cases (31.31%) in the severe group. There was no significant difference in total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), platelet count, red blood cell count and fibrinogen (Fib) between mild group, moderate group and severe group (P>0.05). The serum sodium concentration of severe group was lower than that of mild group and moderate group. Comparing within the Alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), blood lactate dehydrogenase (LDH), procalcitonin (PCT), C-reactive protein (CRP), white blood cell count, γ-glutamyl transpeptidase (GGT), thrombin time (TT), prothrombin time (PT) and D-dimer in three groups (DD), the differences were statistically significant (P<0.05).Pearson correlation analysis showed that blood sodium concentration was negatively correlated with PSI score in CAP patients (P<0.05), while ALT, AST, BUN, LDH, PCT, CRP, white blood cell count, GGT, TT, PT, DD were positively correlated with PSI score (P<0.05). 【Conclusion】The severity of CAP patients is closely related to many factors in the blood, which is helpful to evaluate the severity of CAP patients.
ZHANG Bingzi,LI Shuo. Correlation Analysis of Early Blood Inflammation Indicators and Severity of Disease in Patients with Community-Acquired Pneumonia[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 430-432.
2025, Vol. 42 
