Abstract 【Objective】To investigate the efficacy of local injection of platelet-rich plasma (PRP) in the treatment of patients with diabetic foot refractory ulcer and its effect on serum vascular endothelial growth factor (VEGF) and hyaluronic acid (HA) levels. 【Methods】 A total of 80 patients with diabetic foot refractory ulcer admitted to our hospital from August 2021 to November 2023 were selected and divided into control group (conventional treatment) and observation group (PRP local injection treatment on the basis of control group) according to different treatment methods, with 40 cases in each group. The clinical efficacy, blood perfusion volume, bacterial quantification, ulcer healing (ulcer reduction rate, granulation tissue growth thickness, granulation tissue coverage, ulcer skin grafting time and ulcer healing time), total complication rate, skin temperature of affected foot before and after treatment, ankle brachial index and serum VEGF and HA levels were compared between the two groups. 【Results】The total effective rate, ulcer blood perfusion volume, ulcer shrinkage rate and granulation tissue coverage rate in observation group were higher than those in control group (P<0.05), and the bacterial quantity in observation group was lower than that in control group (P<0.05).The growth thickness of granulation tissue was higher than that of control group (P<0.05).The time of skin grafting and healing of ulcer were shorter than that of control group (P<0.05).After treatment, the skin temperature, ankle-brachial index, VEGF and HA levels in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05). 【Conclusion】 Local injection of PRP in the treatment of patients with diabetic foot refractory ulcer can significantly improve the total effective rate, shorten the healing time of ulcer, and enhance the levels of VEGF and HA in serum, and has a high safety, which is worthy of further clinical application.
CHEN Zhuo,LI Yan,XIE Tian. Effect of Local Injection of Platelet-Rich Plasma in the Treatment of Diabetic Foot Refractory Ulcer and its Influence on Serum VEGF and HA Levels[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 419-422.
[1] 张艳磊,赵文军. 中药塌渍联合康复护理治疗糖尿病足患者的疗效[J].医学临床研究,2024,41(9):1412-1415. [2] LUM Z C, GUNTUPALLI L, HUISH E G .Outcomes of platelet rich plasma injections in the adhesive capsulitis of the shoulder[J].J Orthop,2024,48:42-46. [3] SINGH P R,GILLIES C M,REGILLO D C .Optimizing visual outcomes in patients with neovascular age-related macular degeneration: the potential value of sustained anti-VEGF therapy[J].Ophthalmic Surg Lasers Imaging Retina,2023,54(11):654-659. [4] 詹师,杨召伍,陈山,等. 糖尿病足感染病原微生物分布及风险预测模型的建立[J].中国现代医学杂志,2023,33(10):95-100. [5] 陈冠亚,徐毅. 糖尿病足早期合并感染患者部分血清炎症因子及氧化指标的变化[J].海军医学杂志,2021,42(2):225-227. [6] 王东福,张德林. Ilizarov胫骨横向骨搬移联合PRP治疗糖尿病足难愈性创面的疗效分析[J].医学临床研究,2022,39(12):1810-1813. [7] HO W W S .Achieving the attractive Asian midface profile with hyaluronic acid-based fillers[J].Dermatol Clin,2024,42(1):113-120. [8] 崔亚萍,张巧云,沈娟,等. 自体富血小板血浆联合高压氧治疗老年糖尿病足溃疡的疗效[J].中国老年学杂志,2023,43(19):4721-4724. [9] 兰杰,孔来法,张得意. 富血小板血浆对糖尿病大鼠难愈感染溃疡的作用机制[J].中华医院感染学杂志,2023,33(2):233-237. [10] 王湘琦,赵超然,熊爱兵. 低氘水联合富血小板血浆对大鼠糖尿病溃疡愈合的影响[J].上海交通大学学报(医学版),2020,40(3):326-332. [11] 王倩,颜玺,黄鑫. 富血小板血浆治疗糖尿病足溃疡的研究进展[J].重庆医学,2023,52(1):146-150. [12] 倪芝琳,张传科,何艺羽,等. 富血小板血浆疗法联合腰交感神经节射频热凝术治疗糖尿病足溃疡的临床研究[J].中国疼痛医学杂志,2023,29(4):268-273. [13] 金路,左蕊,刘丽,等. 自体富血小板血浆促糖尿病足溃疡愈合机制研究进展[J].山东医药,2021,61(14):112-115. [14] 胡建武,任继魁,孙晶洁,等. 自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡的临床观察[J].中华烧伤杂志,2017,33(1):46-48.
2025, Vol. 42 
