老年脓毒症患者血清降钙素原水平、APACHE Ⅱ评分的变化及影响因素

doi:10.3969/j.issn.1671-7171.2024.12.022

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1202 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the changes of serum procalcitonin (PCT) level, acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score and its influencing factors in elderly patients with sepsis.【Methods】 Clinical data of 90 elderly patients with sepsis were retrospectively analyzed and divided into high risk group (n=24), middle risk group (n=46) and low risk group (n=20) according to their APACHE Ⅱ scores. PCT level and APACHE Ⅱ score of the three groups were compared, Pearson test was used to analyze the correlation between PCT and APACHE Ⅱ score, and multiple Logistic regression was used to analyze the risk factors affecting senile sepsis. 【Results】The PCT level and APACHE Ⅱ score of the low-risk group were lower than those of the medium-risk group and high-risk group, and the medium-risk group was lower than the high-risk group (P<0.05). Pearson test showed that PCT level was positively correlated with APACHE Ⅱ score (r=0.857, P<0.05). Logistic regression analysis showed that PCT level and APACHE Ⅱ score were independent risk factors for senile sepsis (OR=5.078, 5.043, P<0.05). 【Conclusion】 The occurrence and progression of senile sepsis are related to the increase of serum PCT level and APACHE Ⅱ score, which should be paid attention to clinically.

Key words： Sepsis Procalcitonin APACHE Aged Root Cause Analysis

Received: 26 June 2023

PACS:

R631.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YUAN Erlei
	LI Yang

Cite this article:

YUAN Erlei,LI Yang. Changes of Serum Procalcitonin Level and APACHE Ⅱ Score in Elderly Patients with Sepsis and its Influencing Factors[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1903-1905.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.12.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I12/1903

[1] CHIU C, LEGRANG M. Epidemiology of sepsis and septic shock[J].Curr Opin Anaesthesiol,2021, 34(2): 71-76.
[2] CECCONI M, EVANS L, LEVY M, et al. Sepsis and septic shock[J].Lancet,2018, 392(10): 75-87.
[3] YANG K, FAN M, WANG X H,et al. Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis[J].Cell Death Differ,2022, 29(1): 133-146.
[4] SEVRANSKY J E, ROTHMAN R E, HAGER D N, et al. Effect of vitamin c, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis: thevictas randomized clinical trial[J].JAMA,2021, 325(8): 742-750.
[5] KASPER P, TACKE F, STEFFEN H M, et al. Hepatic dysfunction in sepsis[J].Med Klin Intensivmed Notfmed,2020, 115(7): 609-619.
[6] KOCHANEK M, SHIMABUKURO-VORNHAGEN A, EICHENAUER D A, et al.Cardiovascular therapy for sepsis: when, how and how much?[J].Internist (Berl),2020, 61(10): 997-1001.
[7] BRIEGEL J, BRENNER T.Mortality due to sepsis in germany-a question of the representativeness![J].Anaesthesist,2021,70(8):671-672.
[8] 齐文旗, 张斌, 郑忠骏, 等. 拯救脓毒症运动: 2021年国际脓毒症和脓毒性休克管理指南[J].中华急诊医学杂志, 2021, 30(11): 1300-1304.
[9] FONT M D, THYAGARAJAN B, KHANNA A K. Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making[J].Med Clin North Am,2020, 104(4): 573-585.
[10] GAUER R, FORBES D, BOYER N. Sepsis: diagnosis and management[J].Am Fam Physician,2020, 101(7): 409-418.
[11] 明颖, 闫妹姝, 刘秋霞, 等. 脓毒症患者血清降钙素原、炎症因子水平与APACHE Ⅱ、SOFA评分的相关性[J].现代医学, 2020, 48(3): 357-361.
[12] 郭亚威, 王征, 朱丹丹, 等. 降钙素原联合SOFA评分对老年脓毒症患者预后的评估价值[J].现代生物医学进展, 2019, 19(3): 458-460.
[13] 李桂云, 冯永文, 向兰, 等. 不同预后脓毒症患者血清降钙素原、C反应蛋白与凝血功能指标和APACHE Ⅱ评分的关系分析[J].现代生物医学进展, 2021, 21(2): 274-278.
[14] 欧哲耀, 林文燕, 邓小彦. 扶正解毒汤对脓毒症病人急性生理学和慢性健康状况评价Ⅱ评分及血清降钙素原水平的影响[J].安徽医药, 2023, 27(3): 601-605.
[15] 胡雍军, 张俊鸿, 熊玮. 脓毒症患者血清降钙素原水平的影响因素分析[J].第三军医大学学报, 2020, 42(22): 2219-2223.