瑞马唑仑复合全麻对老年腹腔镜手术患者血流动力学及认知功能的影响

doi:10.3969/j.issn.1671-7171.2024.10.025

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Abstract 【Objective】To explore the effects of remimazolam combined with general anesthesia on hemodynamics and cognitive function in elderly patients undergoing laparoscopic surgery.【Methods】A total of 82 elderly patients undergoing laparoscopic surgery were randomly divided into the observation group and the control group, with 41 patients in each group. The control group received propofol for anesthesia induction, while the observation group received remimazolam. Heart rate (HR) and mean arterial pressure (MAP) changes before and after induction were compared between the two groups. Additionally, the Mini-Mental State Examination (MMSE) scores before and after surgery, anesthesia conditions, and the incidence of adverse reactions in both groups were compared as well. 【Results】 Compared to pre-induction, both groups showed a significant decrease in HR and MAP immediately before intubation and at 1 minute and 3 minutes after intubation (P<0.05). The HR and MAP values at these time points in the observation group were significantly higher than those in the control group (P<0.05). The MMSE scores in both groups significantly decreased from 1 day before surgery to 24 hours after surgery (P<0.05), then significantly increased from 24 hours to 72 hours postoperatively (P<0.05). The MMSE scores in the observation group at 24 hours and 72 hours postoperatively were lower than those in the control group at 24 hours and 72 hours postoperatively (P<0.05),respectively. The time to achieve anesthesia in the observation group was longer than that in the control group (P<0.05), while the recovery time was shorter than that in the control group (P<0.05). There was no statistically significant difference in the length of stay in the post-anesthesia care unit (PACU) between the two groups (P> 0.05). The incidence of hypotension, bradycardia, hypoxemia, and injection pain in the observation group was lower than that in the control group (P<0.05).【Conclusion】 Remimazolam combined with general anesthesia can effectively maintain stable hemodynamics, improve cognitive function, and reduce the incidence of adverse reactions in elderly patients undergoing laparoscopic surgery. It is worthy of clinical promotion and application.

Key words： Laparoscopy Remimazolam Anesthesia, General Hemodynamics Cognition

Received: 20 April 2023

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	YAO Ying
	LI Qiannan

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YAO Ying,LI Qiannan. The Effects of Remimazolam Combined with General Anesthesia on Hemodynamics and Cognitive Function in Elderly Patients Undergoing Laparoscopic Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1543-1546.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.10.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I10/1543

[1] 叶梦霞, 栾国凤, 杜晨, 等. 七氟醚复合麻醉与丙泊酚全凭静脉麻醉对老年患者腹腔镜手术PND的影响[J].国际麻醉学与复苏杂志, 2022, 43(4):371-375.
[2] 巫绍汝, 吴婷婷, 孙艳, 等. 右美托咪定对腹腔镜行结直肠癌手术老年患者术后疼痛及应激反应的影响[J].中华老年医学杂志, 2021, 40(11):1417-1420.
[3] KUTLUSOY S, KOCA E, AYDIN A. Reliability of low-flow anesthesia procedures in patients undergoing laparoscopic cholecystectomy: Their effects on our costs and ecological balance[J].Niger J Clin Pract,2022, 25(11):1911-1917.
[4] 赵晓咏, 夏瑞, 刘香玉, 等. 瑞马唑仑用于腹部手术患者全麻诱导与维持的效果[J].中华麻醉学杂志, 2021, 41(7):823-826.
[5] TANG Y, YANG X, SHU H, et al. Remimazolam besylate for sedation of postoperative patients in intensive care units: a phase Ⅰ, open label, dose-finding study[J].Chin Med J (Engl),2022, 135(17):2134-2136.
[6] 王苹朱, 李辰旭, 黎兰, 等. 认知筛查量表评定老年患者围术期神经功能障碍的研究进展[J].临床麻醉学杂志, 2019, 35(5):511-514.
[7] 李会新, 邢飞, 张卫, 等. 瑞马唑仑和丙泊酚对目标导向血流动力学管理策略老年患者术后恢复质量影响的比较[J].中华麻醉学杂志, 2021, 41(12):1433-1436.
[8] BANSAL T, SINGHAL S, KUNDU K. Prospective randomized double-blind study to evaluate propofol and combination of propofol and sevoflurane as maintenance agents in reducing postoperative nausea and vomiting in female patients undergoing laparoscopic surgery[J].Med Gas Res,2022, 12(4):137-140.
[9] MASUI K. Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia[J].J Anesth,2020, 34(4):479-482.
[10] SHENG X Y, LIANG Y, YANG X Y, et al. Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers[J].Eur J Clin Pharmacol,2020, 76(3):383-391.
[11] 钱焕丽, 李元海, 何川. 瑞马唑仑与咪达唑仑对全身麻醉下行腹腔镜胆囊切除术患者术后认知功能影响的对比研究[J].河北医科大学学报, 2021, 42(6):704-707.
[12] MASUI K, STÖHR T, PESIC M, et al. A population pharmacokinetic model of remimazolam for general anesthesia and consideration of remimazolam dose in clinical practice[J].J Anesth,2022, 36(4):493-505.
[13] YANG M P, LIU X Y, YANG D Q, et al. Effect of remimazolam besylate compared with propofol on the incidence of delirium after cardiac surgery: study protocol for a randomized trial[J].Trials,2021, 22(1):717-724.
[14] SNEYD J R, RIGBY-JONES A E. Remimazolam for anaesthesia or sedation[J].Curr Opin Anaesthesiol,2020, 33(4):506-511.