血清ALT及HBsAg、HBeAb水平与慢性HBV感染患者肝功能及其预后的关系<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.10.002

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Abstract 【Objective】To explore the relationship of serum levels of alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), and hepatitis B e antibody (HBeAb) with liver function and prognosis in patients with chronic hepatitis B virus (HBV) infection. 【Methods】A retrospective analysis of clinical data from 116 patients with chronic HBV infection was conducted. The patients were divided into two groups based on the progression of HBV infection: the good prognosis group with simple chronic HBV infection (n=60) and the poor prognosis group with progression to cirrhosis and liver cancer (n=56). General data, ALT, HBsAg, and HBeAb levels were compared between the two groups. The value of ALT, HBsAg, and HBeAb in predicting poor prognosis and the influencing factors of poor prognosis, as well as the relationship between these three indicators and liver function, were analyzed. 【Results】The proportion of patients with liver function graded as B and C, and the levels of serum ALT, HBsAg, and HBeAb were higher in the poor prognosis group compared to the good prognosis group (P<0.05). Receiver Operating Characteristic (ROC) curve analysis showed that ALT, HBsAg, and HBeAb levels were able to use to predict poor prognosis in patients, with the area under the curve being 0.984, 0.926, and 0.956, respectively (all P<0.05). Multivariate Logistic regression analysis revealed that liver function grades B and C, ALT≥235.67 U/L, HBsAg≥708.45 IU/mL, and HBeAb≥56.153 INH% were risk factors for poor prognosis in patients with chronic HBV infection (P<0.05). Correlation analysis indicated that serum levels of ALT, HBsAg, and HBeAb were positively correlated with liver function grading (P<0.05). 【Conclusion】Serum levels of ALT, HBsAg, and HBeAb are positively correlated with liver function grading in patients with chronic HBV infection. Liver function grades B and C, ALT≥235.67 U/L, HBsAg≥708.45 IU/mL, and HBeAb ≥ 56.153 INH% are risk factors for poor prognosis in patients with chronic HBV infection. These indicators can serve as important markers for monitoring the condition of chronic HBV infection patients, providing references for clinical diagnosis and treatment.

Key words： Hepatitis B Virus Chronic Disease Hepatitis B Surface Antigens Alanine Transaminase Liver Function Tests

Received: 24 October 2023

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R512.62

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	WU Liangfei
	SUN Zhigang
	YI Benxi

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WU Liangfei,SUN Zhigang,YI Benxi. Relationship of Serum Levels of ALT, HBsAg, and HBeAb with Liver Function and Prognosis in Patients with Chronic HBV Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1461-1464.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.10.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I10/1461

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