老年中重度烧伤患者切痂植皮术中使用右美托咪定联合咪达唑仑的麻醉效果

doi:10.3969/j.issn.1671-7171.2024.09.015

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Abstract 【Objective】To investigate the anesthetic effect of dexmedetomidine (Dex) combined with midazolam in elderly patients with severe burns undergoing scab excision and skin grafting surgery. 【Methods】A total of 102 elderly patients with moderate to severe burns were randomly divided into the observation group and the control group, with 51 cases in each group. The control group was maintained with propofol anesthesia, while the observation group was maintained with Dex combined with midazolam anesthesia. The heart rate (HR) and mean arterial pressure (MAP) levels were compared between two groups at different time points during and after surgery; Two groups of patients were compared in terms of surgical conditions and plasma cortisol (COR), adrenaline (E), and norepinephrine (NE) levels before and after surgery; Two groups of patients were compared in terms of postoperative pain [visual analog scale (VAS)], sedation effect (Ramsay sedation score), agitation incidence, and incidence of adverse reactions.【Results】The HR of the observation group was lower than that of the control group at the end of surgery, before extubation, and 30 minutes after extubation (P<0.05), while the MAP was higher than that of the control group (P<0.05). At 30 minutes postoperatively, the plasma levels of COR, E, and NE in the observation group were lower than those in the control group (P<0.05). The VAS score of the observation group was lower than that of the control group (P<0.05), the Ramsay sedation score was higher than that of the control group (P<0.05), and the incidence of agitation was lower than that of the control group (P<0.05). The awakening time of the observation group was shorter than that of the control group (P<0.05), and there was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】Dex combined with midazolam can effectively reduce postoperative stress response, stabilize hemodynamics, shorten recovery time, reduce postoperative pain and agitation incidence in elderly patients with moderate to severe burns undergoing scab and skin grafting surgery, and has good safety.

Key words： Burns/SU Skin Transplantation Dexmedetomidine/TU Midazolam/TU Anesthesia

Received: 10 May 2024

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R644

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WANG Haijun. The Anesthesia Effect of Dexmedetomidine Combined with Midazolam in Elderly Patients with Moderate to Severe Burns Undergoing Scab Excision and Skin Grafting Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1335-1338.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.09.015 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I9/1335

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