血清谷丙转氨酶/谷草转氨酶联合癌胚抗原预测肝细胞癌术后患者预后的价值

doi:10.3969/j.issn.1671-7171.2024.06.028

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Abstract 【Objective】 To investigate the predictive value of serum alanine aminotransferase/aspartate aminotransferase(ALT/AST) combined with carcinoembryonic antigen(CEA) for postoperative prognosis in patients with hepatocellular carcinoma(HCC).【Methods】 Ninety-one HCC patients treated surgically in our hospital were followed up for three years postoperatively. The survival status was recorded, and clinical data of deceased and surviving patients were compared. Factors influencing mortality and the predictive value of serum ALT/AST combined with CEA for prognosis were analyzed.【Results】 Of the 91 patients, 9 were lost to follow-up. Among the remaining 82 patients, 28 died and 54 survived. The proportion of poorly differentiated tumors, Child-Pugh grade B and distant metastasis in the deceased group were higher than those in the surviving group(P<0.05). The serum CEA levels in the deceased group were higher than that in the surviving group(P<0.05). The ALT/AST ratio in the deceased group was lower than that in the surviving group(P<0.05). Distant metastasis, ALT/AST, and CEA were independent risk factors for mortality(OR=4.158, 4.039, and 4.067, respectively,P<0.05). The specificity and area under the curve(AUC) for predicting postoperative mortality in HCC patients using serum ALT/AST combined with CEA were 96.30% and 0.946, respectively, indicating higher predictive value than using ALT/AST or CEA alone.【Conclusion】 Clinical detection of serum ALT/AST and CEA can serve as sensitive indicators for predicting postoperative mortality in HCC patients, with combined detection offering higher predictive value.

Key words： Carcinoma, Hepatocellular/SU Alanine Transaminase/BL Aspartate Aminotransferases/BL Carcinoembryonic Antigen

Received: 26 August 2023

PACS:

R735.7

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	LI Hailin
	LIU Dong
	TANG Jinyu

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LI Hailin,LIU Dong,TANG Jinyu. The Predictive Value of Serum Alanine Aminotransferase/Aspartate Aminotransferase Combined with Carcinoembryonic Antigen for Postoperative Prognosis in Patients with Hepatocellular Carcinoma[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 900-902.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.06.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I6/900

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