双向孟德尔随机化分析胃癌和肌肉减少症的遗传因果关系

doi:10.3969/j.issn.1671-7171.2024.06.011

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1287 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To analyze the potential causal relationship between sarcopenia and gastric cancer at the genetic level using two sample bidirectional Mendelian randomization(MR).【Methods】Significant instrumental variables(IV) were obtained from publicly available genome-wide association studies(GWAS) statistical data for two sample MR analysis. Sensitivity analysis was performed using methods such as Cochran's Q test to ensure that IV met the three major hypotheses. Methods such as inverse variance weighting(IVW) were used to evaluate the bidirectional causal relationship between gastric cancer and sarcopenia.【Results】The positive MR analysis results showed that no causal relationship was found between gastric cancer and limb muscle mass(ALM)(OR=-0.019, P=0.446), left hand grip strength(OR=-0.008, P=0.059), and right hand grip strength(OR=-0.010, P=0.220)(P>0.05); No causal relationship was found between the above indicators in the reverse MR analysis(P>0.05).【Conclusion】There is no direct causal relationship between gastric cancer and sarcopenia at the genetic level.

Key words： Stomach Neoplasms Sarcopenia Mendelian Randomization Analysis Heredity

Received: 24 April 2024

PACS:

R735.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.06.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I6/838

[1] PETERMANN-ROCHA F, BALNTZI V, GRAY S R, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis[J].J Cachexia Sarcopenia Muscle,2022, 13(1): 86-99.
[2] DHILLON R J, HASNI S. Pathogenesis and management of sarcopenia[J].Clin Geriatr Med,2017, 33(1): 17-26.
[3] CHO M R, LEE S, SONG S K. A Review of sarcopenia pathophysiology, diagnosis, treatment and future direction [J].J Korean Med Sci,2022, 37(18): e146.
[4] GAO Q Q, HU K Y, YAN C J, et al. Associated factors of sarcopenia in community-dwelling older adults: a systematic review and meta-analysis [J].Nutrients,2021, 13(12):4291.
[5] HAIDUCU C, BUZEA A, MIREA L E, et al. The prevalence and the impact of sarcopenia in digestive cancers. A systematic review [J].Rom J Intern Med,2021, 59(4): 328-344.
[6] SUN M Y, CHANG C L, LU C Y, et al. Sarcopenia as an independent risk factor for specific cancers: a propensity score-matched Asian population-based cohort study [J].Nutrients,2022, 14(9):1910.
[7] SIERZEGA M, CHRZAN R. Sarcopenia associated with gastric cancer [J].J Surg Oncol,2019, 120(8): 1509.
[8] DAVEY SMITH G, HEMANI G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies [J].Hum Mol Genet,2014, 23(R1): R89-R98.
[9] ISHIGAKI K, AKIYAMA M, KANAI M, et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases [J].Nat Genet,2020, 52(7): 669-679.
[10] HIRATA M, KAMATANI Y, NAGAI A, et al. Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200 000 patients with 47 common diseases [J].J Epidemiol,2017, 27(3S): S9-S21.
[11] COLLINS R. What makes UK Biobank special? [J].Lancet,2012, 379(9822): 1173-1174.
[12] PEI Y F, LIU Y Z, YANG X L, et al. The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study [J].Commun Biol,2020, 3(1): 608.
[13] CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis [J].Age Ageing,2019, 48(1): 16-31.
[14] BURGESS S, THOMPSON S G, COLLABORATION C C G. Avoiding bias from weak instruments in Mendelian randomization studies [J].Int J Epidemiol,2011, 40(3): 755-764.
[15] BOWDEN J, DAVEY SMITH G, HAYCOCK P C, et al. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator [J].Genet Epidemiol, 2016, 40(4): 304-314.
[16] VERBANCK M, CHEN C Y, NEALE B, et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases [J].Nat Genet,2018, 50(5): 693-698.
[17] SUROV A, WIENKE A. Prevalence of sarcopenia in patients with solid tumors: A meta-analysis based on 81,814 patients [J].JPEN J Parenter Enteral Nutr,2022, 46(8): 1761-1768.
[18] STEWART O A, WU F, CHEN Y. The role of gastric microbiota in gastric cancer [J]. Gut Microbes,2020, 11(5): 1220-1230.
[19] SHA T T, LI W, HE H Y, et al. Causal relationship of genetically predicted serum micronutrients levels with sarcopenia: a mendelian randomization study [J].Front Nutr,2022, 9: 913155.
[20] KIM Y M, KIM J H, BAIK S J, et al. Sarcopenia and sarcopenic obesity as novel risk factors for gastric carcinogenesis: a health checkup cohort study [J].Front Oncol,2019, 9: 1249.
[21] PATAKY M W, YU C S, NIE Y, et al. Skeletal muscle fiber type-selective effects of acute exercise on insulin-stimulated glucose uptake in insulin-resistant, high-fat-fed rats [J].Am J Physiol Endocrinol Metab,2019, 316(5): E695.
[22] LUO Y, LIU J S, DAI B, et al. The influence of metabolic syndrome on gastric cancer: A meta-analysis [J].Asian J Surg,2021, 44(12): 1596-1597.
[23] LARSSON S C, SPYROU N, MANTZOROS C S. Body fatness associations with cancer: evidence from recent epidemiological studies and future directions [J].Metabolism,2022, 137: 155326.