丹参川芎嗪注射液联合曲美他嗪对不稳定型心绞痛患者心电图、心功能的影响

doi:10.3969/j.issn.1671-7171.2024.05.029

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Abstract 【Objective】To explore the effects of Danshen Chuanxiongqin Injection combined with Trimetazidine on electrocardiogram and cardiac function in patients with unstable angina pectoris (UAP).【Methods】A retrospective analysis was conducted on the clinical data of 106 UAP patients admitted to our hospital from January 2021 to May 2023. According to different treatment methods, they were divided into a control group and an observation group, with 53 cases in each group. The control group was treated with trimetazidine, while the observation group was treated with Danshen Chuanxiongqin Injection+trimetazidine. We compared between two groups in terms of the clinical efficacy, seizure frequency, nitroglycerin dosage, duration, cardiac function [cardiac output (CO), left ventricular ejection fraction (LVEF), stroke output (SV)], and electrocardiogram changes [ST segment depression amplitude], ST segment depression frequency, serum biochemical indicators, angiopoietin like protein 2 (Angptls2), oxidized low-density lipoprotein (ox-LDL),C1q tumor necrosis factor related protein 1 (CTRP1) and occurrence of adverse reactions.【Results】The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the seizure frequency, nitroglycerin dosage, and duration of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05); CO, LVEF and SV of two sets were both higher than those before treatment, and the observation group was higher than the control group, with a statistically significant difference (P<0.05); The ST segment depression amplitude and the number of ST segment depressions of two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05); The levels of Serum Angptls2, ox-LDL and CTRP1 of the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】The combination of Danshen Chuanxiongqin Injection and Trimetazidine has a good clinical efficacy in the treatment of UAP, which helps to alleviate patient symptoms, improve heart function, and has high safety.

Key words： Angina, Unstable/DT Danshen Chuanxiongqin Zhusheye/TU Trimetazidine/TU Electrocardiography

Received: 24 August 2023

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R541.42

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	HE Zhaoguo
	ZOU Yang

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HE Zhaoguo,ZOU Yang. The Effects of Danshen Chuanxiongqin Injection Combined with Trimetazidine on Electrocardiogram and Cardiac Function Levels in Patients with Unstable Angina Pectoris[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 747-749.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.05.029 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I5/747

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