瑞马唑仑对老年NSCLC根治性手术患者手术应激反应、术后苏醒期质量及拔管时间的影响

doi:10.3969/j.issn.1671-7171.2024.03.012

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Abstract 【Objective】To explore the effects of remimazolam on stress response, postoperative recovery quality, and extubation in elderly patients undergoing radical surgery for non-small cell lung cancer(NSCLC).【Methods】Eighty patients undergoing radical NSCLC surgery in The First Affiliated Hospital of Xinxiang Medical University were randomly divided into two groups, with 40 patients in each group. The control group received propofol, while the observation group was induced and maintained with remimazolam anesthesia. Levels of adrenocorticotropic hormone(ACTH) and nitric oxide(NO) were compared pre-surgery and post-surgery between the two groups. Additionally, heart rate(HR) and mean arterial pressure(MAP) were compared at different time points: before anesthesia induction(T₁), within 1 minute of intubation(T₂), 30 minutes after surgery started(T₃), at the end of surgery(T₄), and 10 minutes after extubation(T₅). Postoperative recovery quality and the incidence of coughing were also compared between the groups. 【Results】 Compared to pre-surgery levels, both groups showed a significant increase in ACTH level and a decrease in NO level(P<0.05), but there was no significant difference between the groups(P>0.05). Both groups had significantly lower HR and MAP at T₂ and T₃ compared to T₁(P<0.05). HR and MAP levels at T₂ were higher in the observation group compared to the control group(P<0.05). There was no significant difference between the two groups in terms of postoperative recovery quality measured by bispectral index(BIS), postoperative visual analogue scale(VAS) scores, and agitation(P>0.05). The observation group had shorter eye-opening time, extubation time, and duration of stay in the post-anesthesia care unit(PACU) compared to the control group(P<0.05). The incidence of coughing was lower in the observation group(P<0.05). 【Conclusion】 The use of remimazolam for anesthesia induction in elderly patients undergoing radical NSCLC surgery can maintain hemodynamic stability, improve the quality of recovery period, and reduce the incidence of coughing during extubation.

Key words： Carcinoma, Non-Small-Cell Lung/SU Remimazolam Stress, Physiological Anesthesia Recovery Period

Received: 11 August 2023

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R734.2

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	Articles by authors
	JIA Zhijie
	ZHANG Xiaoran
	DUAN Wenjiao

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JIA Zhijie,ZHANG Xiaoran,DUAN Wenjiao. The Effect of Remimazolam on Surgical Stress Response, Quality of Postoperative Recovery, and Extubation in Elderly Patients Undergoing Radical Surgery for NSCLC[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 364-367.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.03.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I3/364

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