纤维蛋白原与前白蛋白比值、血红蛋白与红细胞分布宽度比与结直肠癌患者预后的关系

doi:10.3969/j.issn.1671-7171.2024.03.010

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Abstract 【Objective】To investigate the relationship between fibrinogen to prealbumin ratio(FPR), hemoglobin to red blood cell distribution width ratio(HRR) and prognosis of colorectal cancer patients. 【Methods】A total of 92 patients with colorectal cancer who underwent surgery were followed up for 3 years. According to the prognosis, they were divided into good prognosis group(no recurrence, metastasis or death) and poor prognosis group(recurrence, metastasis or death). The clinical data, FPR and HRR levels of the two groups were compared, and the factors affecting the prognosis of the patients were analyzed; Receiver operating characteristic(ROC) curve was used to analyze the predictive efficacy of FPR and HRR levels on the prognosis of patients. 【Results】 The incidence of poor prognosis in colorectal cancer patients within 3 years after operation was 22.83%(21/92). The FPR level in the poor prognosis group was higher than that in the good prognosis group, and the HRR level was lower than that in the good prognosis group(P<0.05). ROC curve showed that the sensitivity of FPR, HRR and their combination to predict the prognosis of patients were 76.20%, 57.10% and 90.50%, respectively, and the specificity was 77.50%, 69.00% and 88.70%, respectively. The area under the curve(AUC) was 0.804, 0.722 and 0.899, respectively. The proportion of poorly differentiated and TNM stage Ⅲa in the poor prognosis group was higher than that in the good prognosis group(P<0.05); There was no significant difference in gender, age, maximum diameter of tumor, tumor location, pathological type between the two groups(P>0.05). Cox multivariate analysis showed that TNM stage Ⅲa and FPR were risk factors for the prognosis of patients, while HRR was a protective factor for the prognosis of patients(P<0.05). The survival curve of patients with high FPR level was significantly different from that of patients with low FPR level(P<0.05). The survival curve of patients with low HRR level was significantly different from that of patients with high HRR level(P<0.05). 【Conclusion】The detection of FPR and HRR levels in patients with colorectal cancer can be used to predict the prognosis of patients, and the combined predictive value of the two is better.

Key words： Colorectal Neoplasms Fibrinogen Prealbumin Hemoglobins Erythrocyte Indices

Received: 06 July 2023

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R735.35

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Cite this article:

HE Jie. Relationship between Fibrinogen to Prealbumin Ratio, Hemoglobin to Red Blood Cell Distribution Width Ratio and Prognosis of Colorectal Cancer Patients[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 356-359.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.03.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I3/356

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