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| The Effect of Levosimendan Combined with Tofacilitaxel in the Treatment of Acute Decompensated HFpEF |
| MA Rui, LEI Xueting |
| Shaanxi Aerospace Hospital, Xi'an Shaanxi 710025 |
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Abstract 【Objective】To explore the clinical efficacy of levosimendan combined with tofacilitan in patients with acute decompensated ejection fraction preserved heart failure (HFpEF). 【Methods】A total of 78 patients with acute decompensated HFpEF admitted to Shaanxi Aerospace Hospital from March 2020 to November 2021 were selected and randomly divided into an observation group and a control group using a random number table method, with 39 cases in each group. The control group was treated with Tovastatin tablets, while the observation group was treated with a combination of levosimendan on the basis of the control group. Both groups of patients were evaluated for cardiac function indicators [left ventricular end diastolic/systolic diameter (LVEDD/LVESD) and left ventricular ejection fraction (LVEF)], myocardial injury related indicators [heart type fatty acid binding protein (hFABP) and N-terminal B-type brain natriuretic peptide(NT-proBNP)], and cardiac function related inflammatory factor indicators [high-sensitivity C-reactive protein (hs-CRP) and hypoxia inducible factor 1α (HIF-1α)] before and 1 week after treatment Hemodynamic indicators [heart rate (HR), stroke output (SV)] and 24-hour urine output levels, and adverse drug reactions were recorded.【Results】After treatment, LVEDD and LVESD in both groups were lower than before treatment, and LVEF was higher than before treatment. LVEDD and LVESD in the observation group were lower than those in the control group, and LVEF was higher than those in the control group, with statistical significance (P<0.05); The serum levels of hFABP, NT-proBNP, hs-CRP, and HIF-1α in two groups of patients were lower than before treatment, and the observation group was lower than the control group (P<0.05); The SV and 24-hour urine output of the two groups of patients were higher than before treatment, while the HR was lower than before treatment. The observation group had higher SV and 24-hour urine output than the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). 【Conclusion】The combined use of levosimendan and tofapetam in the treatment of acute decompensated HFpEF patients is beneficial for the recovery of cardiac function, stable hemodynamics, and good safety.
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Received: 06 October 2022
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2023, Vol. 40 
