急性ST段抬高型心肌梗死不同心电图表现患者心肌损伤标志物及无复流风险观察

doi:10.3969/j.issn.1671-7171.2023.12.026

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Abstract 【Objective】 To explore the correlation between electrocardiogram ischemic grading, myocardial injury markers, and no reflow in patients with acute ST segment elevation myocardial infarction. 【Methods】A retrospective analysis was conducted on the clinical data of 80 patients with acute ST segment elevation myocardial infarction admitted to our hospital from January 2019 to January 2022. According to the electrocardiogram ischemic grading, they were divided into grade Ⅱ ischemic group (n=32) and grade Ⅲ ischemic group (n=48). We compared the levels of two groups of myocardial injury biomarkers [high-sensitivity troponin (hs-cTnI), N-terminal B-type brain natriuretic peptide(NT-proBNP), and creatine kinase isoenzyme (CK-MB)], and used receiver operating characteristic (ROC) curves to analyze the value of myocardial injury biomarker indicators in predicting grade Ⅲ ischemia in acute ST segment elevation myocardial infarction. Logistic multiple factor stepwise regression was used to analyze the influencing factors of electrocardiogram ischemia grade Ⅲ in patients with acute ST segment elevation myocardial infarction. 【Results】The proportion of patients in the grade Ⅱ ischemic group without reflow was lower than that in the grade Ⅲ ischemic group, and the levels of hs-cTnI and NT-proBNP were lower than those in the grade Ⅲ ischemic group. The levels of CK-MB were higher than those in the grade Ⅲ ischemic group (P<0.05). ROC curve analysis showed that hs-cTnI, NT-proBNP, and CK-MB levels can all be used for predicting grade Ⅲ ischemia in acute ST segment elevation myocardial infarction, with areas under the curves of 0.861, 0.706, and 0.792 (P<0.05), respectively. Multivariate logistic regression analysis showed that no reflow, hs-cTnI ≥ 1.545 ng/mL, NT-proBNP ≥ 1075.005 ng/mL, and CK-MB<38.253 ng/mL were risk factors for ischemic grade Ⅲ on electrocardiogram in acute ST segment elevation myocardial infarction (P<0.05). 【Conclusion】There are differences in the levels of myocardial injury markers and reflow in patients with acute ST segment elevation myocardial infarction with different electrocardiographic ischemic grades, and myocardial injury markers and no reflow can be used to predict the ischemic grade of acute ST segment elevation myocardial infarction electrocardiograms.

Key words： ST Elevation Myocardial Infarction Acute Disease Electrocardiography Troponin/BL Natriuretic Peptide, Brain/BL Creatine Kinase, MB Form/BL

Received: 10 November 2022

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R542.22

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MAO Cun. Observation of Myocardial Injury Markers and No Risk of Reflow in Patients with Acute ST Segment Elevation Myocardial Infarction with Different Electrocardiogram Manifestations[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1912-1915.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.12.026 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I12/1912

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