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| Efficacy of Estrogen Combined with Medroxyprogesterone Acetate in the Treatment of Acute Abnormal Uterine Bleeding |
| GAO Jia, CHEN Wei |
| Department of Obstetrics and Gynecology,Xi'an People's Hospital(Xi'an Fourth Hospital),Xi'an Shaanxi 710199 |
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Abstract 【Objective】To study the efficacy of estrogen combined with medroxyprogesterone acetate in the treatment of acute abnormal uterine bleeding. 【Methods】A total of 118 patients with acute abnormal uterine bleeding from April 2019 to February 2022 were selected and divided into the observation group(n=59) and the control group(n=59) by random number table method. The control group was treated with medroxyprogesterone acetate,while the observation group was treated with estrogen in addition to medroxyprogesterone acetate. Patients in both groups received treatment for 3 months. The clinical efficacy,hemostatic effect,incidence of adverse reactions,serum luteinizing hormone(LH),estradiol(E2),follicle-stimulating hormone(FSH),endometrial thickness,and health-promoting lifestyle scale(HPLP-Ⅱ) scores were compared between the two groups before and after treatment.【Results】The total effective rate of the observation group(94.92%) was higher than that of the control group(79.66%)(P<0.05). The duration of complete hemostasis and the time to control bleeding in the observation group were shorter than those in the control group(P<0.05). Compared to before treatment,the serum levels of FSH,E2,and LH in both groups decreased after treatment,and the thickness of the endometrium became thinner(P<0.05). And the changes in the observation group were more obvious(P<0.05). After treatment,the scores of HPLP-Ⅱ in both groups increased(P<0.05),and the score in the observation group was higher than that in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】Estrogen combined with medroxyprogesterone acetate is effective in the treatment of patients with acute abnormal uterine bleeding,which can reduce the level of sex hormones and endometrial thickness,improve the quality of life of patients,and is safe and reliable.
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Received: 01 November 2022
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2023, Vol. 40 
