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| Relationship of Oxidative Stress,BDNF,and IGF-1 Levels with Severity of Epilepsy |
| CHEN Xiao-ni, TAN Hui-hui, YIN Yan-ling, et al |
| Department Neurology,Xi'an No.3 Hospital,Xi'an Shaanxi 710021 |
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Abstract 【Objective】 To explore the relationship of the severity of epileptic seizures with the levels of oxidative stress,brain derived neurotrophic factor (BDNF),and insulin like growth factor (IGF-1). 【Methods】 According to the severity of seizures,198 patients with epilepsy admitted to our hospital were divided into the mild group of 71 cases,the moderate group of 74 cases,and the severe group of 53 cases. Meanwhile,68 healthy individuals who underwent physical examination at the same time in our hospital were selected as the control group. The general data and serum oxidative stress indicators (MDA,CAT,SOD,T-AOC),as well as serum BDNF and IGF-1 levels were measured and compared among the four groups. We analyzed the correlation between the levels of various indicators and the severity of epilepsy in patients with different grades of epilepsy to show the relationship of severity of epilepsy with serum levels of MDA,CAT,SOD,T-AOC,BDNF,IGF-1. 【Results】 The levels of serum CAT,SOD and T-AOC in patients with epilepsy of different grades were significantly lower than those in the control group,while the level of MDA was significantly higher than that in the control group. As the severity of the disease increased,the levels of CAT,SOD,and T-AOC showed a downward trend,while the level of MDA showed a increase trend (all P<0.05). Serum BDNF level in patients with epilepsy of different severities was significantly lower than that in the control group,while IGF-1 level was significantly higher than that in the control group. As the severity of the disease increased,BDNF tended to decrease,while IGF-1 tended to increase (all P<0.05). Pearson correlation analysis showed that levels of serum CAT,SOD,T-AOC,and BDNF were negatively correlated with the severity of the disease (P<0.05),while MDA and IGF-1 levels were positively correlated with the severity of the disease (P<0.05). BDNF level was negatively correlated with MDA level,while it was positively correlated with CAT,SOD,and T-AOC levels. The level of IGF-1 was positively correlated with MDA level,and it was negatively correlated with CAT,SOD,and T-AOC levels (P<0.05). 【Conclusion】 There are significant differences in the levels of oxidative stress,BDNF,IGF-1,and BDNF,IGF-1 in epileptic patients with different severity of illness. The disease severity is significant correlation to the levels of oxidative stress,BDNF and IGF-1 in epileptic patients.
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Received: 26 June 2022
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[1] 李军强,刘鹏鹏,令调文,等.癫痫住院患者抗癫痫药物和病因及发作形式的回顾性研究[J].中国神经精神疾病杂志,2018,44(5):266-271.
[2] 张冉冉,刘学伍.炎症反应和氧化应激在癫痫中的作用研究进展[J].癫痫杂志,2021,7(2):142-146.
[3] 闻红斌.血清BDNF、IGF-1及Hcy与癫痫患者认知功能损害关系研究[J].基因组学与应用生物学,2018,37(10):4547-4552.
[4] ANTONY T,KANMANI J,ANJANA A P. Study to assess the seizure severity,depression and quality of life among patients with epilepsy at AIMS,Kochi[J].Indian J Public Health Res Development,2018,9(4):1814-1839.
[5] 梁锦平.国际抗癫痫联盟新修订发作类型操作性分类的特征及解读[J].中华神经科杂志,2019,52(1):71-78.
[6] GREEN R,ABE C,DENNEY D A,et al. Physical activity status and quality of life in patients with epilepsy-survey from level four epilepsy monitoring units[J].Epilepsy Res,2021,9(3):96-98.
[7] 郭微娟,杨柳,武东,等. 癫痫患者血清Hcy代谢与神经细胞因子、凋亡分子含量的相关性[J].海南医学院学报,2017,23(13):1867-1873.
[8] 孙光涛,戚询中,邹春颖,等.基于Nrf2-ARE信号通路探析己酮可可碱对癫痫大鼠脑内氧化应激的影响[J].医学研究生学报,2020,33(2):144-148.
[9] 邵延萱,罗文哲,薛晴,等.柑橘素对癫痫大鼠海马组织氧化应激因子及Caspase-9的作用[J].中国老年学杂志,2021,41(20):4491-4494.
[10] 夏顺刚,卢红.奥卡西平对儿童病毒性脑炎继发癫痫患者的炎性因子、免疫功能及氧化应激的影响[J].中国免疫学杂志,2019,35(9):1122-1125.
[11] 高飞,石少亭,折潇,等.癫痫患者血清氧化应激水平变化及其与癫痫发作严重程度的相关性[J].山东医药,2020,60(21):84-86.
[12] 张军武,李培育.癫痫复杂部分性发作患者认知功能与磁共振波谱及血清BDNF、IGF-1水平的相关性分析[J].检验医学与临床,2018,15(2):237-239. |
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2023, Vol. 40 
