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| Serum 25-hydroxyvitamin D Level in Assessing Prognosis of Patients with Ischemic Stroke |
| BI Qing-guo, DI Yong, ZHA Wu-hao, et al |
| Department of Emergency Critical Care Medicine,Zhoupu Hospital of Shanghai Pudong New Area (Zhoupu Hospital Affiliated to Shanghai Medical College),Shanghai 201318 |
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Abstract 【Objective】 To investigate the value of serum fat-soluble vitamin (25-hydroxyvitamin D,25-OH-VD) in evaluating the prognosis of patients with ischemic stroke. 【Methods】 The data of 1000 cases of ischemic stroke admitted to two hospitals were analyzed retrospectively. According to the survival conditions,the patients were divided into the good and the bad prognosis groups,with 510 and 490 cases in each group,respectively. Basic data of the two groups [age,sex,body mass index (BMI),smoking history,infarct size,blood sugar,body temperature,NIHSS score,blood pressure,25-OH-VD] were compared. The predictive value of 25-OH-VD was drawn by ROC curve and analyze the risk factors of poor prognosis of ischemic stroke was analyzed by logistic regression.【Results】 The proportion of patients with infarct size ≥1.5 cm2,hyperglycemia,elevated body temperature,NIHSS score ≥21 and hypertension in the poor prognosis group was significantly higher than that in the good prognosis group,while 25-OH-VD was significantly lower than that in the good prognosis group (P<0.05).By ROC analysis,the area under the curve of 25-OH-VD was 0.680,the optimal cut-off value was 24.500,the sensitivity was 0.450,and the specificity was 0.700,all of which were (P<0.05).Logistic regression analysis showed that infarct size ≥1.5 cm2,hyperglycemia,elevated body temperature,NIHSS score ≥21,hypertension and 25-OH-VD < 24.500 ng/mL were risk factors for poor prognosis in patients with ischemic stroke (P<0.05).【Conclusion】 There are many risk factors affecting the poor prognosis of patients with ischemic stroke,such as infarct size≥1.5 cm2,hyperglycemia,elevated body temperature,NIHSS score≥21 points,hypertension and 25-OH-VD. Of which,25-OH-VD<24.500 ng/mL is the best cutoff value for patients with ischemic stroke and it has a certain reference value in the process of preventing patients with ischemic stroke.
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Received: 26 August 2022
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2023, Vol. 40 
