丁苯酞联合长春西汀治疗急性脑梗死的疗效及对脑血流动力学和认知功能的影响

doi:10.3969/j.issn.1671-7171.2022.11.009

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1162 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To observe the effects and safety of butylphthalide combined with vinpocetine on cerebral hemodynamics and cognitive function in the treatment of acute cerebral infarction(ACI)patients. 【Methods】A total of 120 ACI patients in our hospital were randomly divided into two groups with 60 cases in each group.The control group was given vinpocetine,while the observation group was given butylphthalide on the basis of the control group.Both groups were treated for 14 d.The clinical efficacy,NIHSS score,MMSE score,cerebral hemodynamics [peak flow velocity (V_p),average flow velocity (V_m),cerebrovascular reserve (CVR)] and serum homocysteine (Hcy),6-keto-prostaglandin-F1A (6-K-PGF1a) and VEGF were compared between the two groups. 【Results】The total effective rate of the observation group was higher than that of the control group ( P<0.05).Compared to before treatment,the NIHSS score of the two groups decreased after treatment; And NIHSS score of the observation group was significantly lower than that of the control group.After treatment,the MMSE score of the two groups increased and MMSE of the observation group was significantly higher than that of the control group (P<0.05).Compared with before treatment,Vp,V_m and CVR of the two groups showed an increasing trend after treatment,and those values in the observation group was significantly higher than those in the control group (P<0.05).Compared with before treatment,the Hcy of the two groups decreased after treatment,and the decreasing of the observation group was significantly lower than that of the control group.After treatment,the levels of 6-k-PGF1a and VEGF increased,and the increasing of the observation group was significantly higher than that of the control group (P<0.05).The incidence of adverse reactions in two group was not significantly different (P>0.05). 【Conclusion】Butylphthalide injection combined with vinpocetine injection have significant efficacy in the treatment of ACI,which can significantly improve cerebral hemodynamics,reduce the levels of Hcy,and increase the levels of 6-k-PGF1a and VEGF to promote the recovery of neural function and cognitive function,without increasing adverse drug reactions.

Key words： Brain Infarction/DT Acute Disease Propiophenones/TU Vinca Alkaloids/TU Hemorheology Treatment Outcome

Received: 22 December 2021

PACS:

R743.33

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Dong-zi
	CHEN Bin

Cite this article:

ZHANG Dong-zi,CHEN Bin. Effects of Butylphthalide Injection Combined with Vinpocetine Injection on Cerebral Hemodynamics and Cognitive Function of Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1630-1633.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.11.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I11/1630

[1] BONG J B.Acute cerebral infarction after pyrethroid ingestion[J].Geriatr Gerontol Int,2017,17(3):510-511.
[2] SUGIDACHI A,MIZUNO M,Ohno K,et al.The active metabolite of prasugrel,R-138727,improves cerebral blood flow and reduces cerebral infarction and neurologic deficits in a non-human primate model of acute ischaemic stroke[J].Eur J Pharmacol,2016,788:132-139.
[3] 王素洁,李培,刘江,等.长春西汀联合血栓通治疗急性脑梗死的临床观察[J].中国药房,2017,28(36):5079-5082.
[4] 陈聪,苏庆杰,吴海荣,等.丁苯酞注射液联合依达拉奉注射液治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2018,34(4):395-398.
[5] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国缺血性脑卒中风险评估量表使用专家共识[J].中华神经科杂志,2016,49(7):519-525.
[7] WANG T,GONG Y,SHI Y,et al.Feasibility of dual-low scheme combined with iterative reconstruction technique in acute cerebral infarction volume CT whole brain perfusion imaging[J].Exp Ther Med,2017,14(1):163-168.
[8] 段瑞生,齐亚超,尹楠,等.丁苯酞对血管性轻度认知功能障碍患者S100和MBP的影响[J].中国医院药学杂志,2017,37(9):866-868.
[9] 许乐宜,王静予,孔令军,等.大骨瓣减压合并颞肌敷贴对大面积脑梗死患者血流动力学及神经功能的影响[J].中风与神经疾病杂志,2018,35(11):51-55.
[10] 宋彦,丁旭萌,李旭,等.超声监测老年进展性脑梗死与颈动脉斑块稳定性的关系及进展性脑梗死的危险因素[J].中国老年学杂志,2018,38(23):5670-5673.
[11] SUN Q,JIA X,GAO J,et al.Association of serum homocysteine levels with the severity and calcification of coronary atherosclerotic plaques detected by coronary CT angiography.[J].Int Angiol,2014,33(4):316-323.
[12] 宋轶群,刘梅,于广.丁苯酞对急性脑梗死患者认知功能和血清学指标的影响及二者相关性分析[J].中国药房,2017,28(2):243-246.
[13] TANG S C,LUO C J,ZHANG K H,et al.Effects of dl-3-n-butylphthalide on serum VEGF and bFGF levels in acute cerebral infarction[J].Eur Rev Med Pharmacol Sci,2017,21(19):4431-4436.