Liliequist膜不同处理方式对动脉瘤性蛛网膜下腔出血患者并发症发生风险的影响

doi:10.3969/j.issn.1671-7171.2022.10.009

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Abstract 【Objective】 To study the effect of different treatments of Liliequist membrane on the risk of complications in patients with aneurysmal subarachnoid hemorrhage.【Methods】A total of 70 patients with aneurysmal subarachnoid hemorrhage admitted to our hospital from January 2020 to January 2022 were selected as the study subjects. They were randomly divided into the observation group (35 cases) and the control group (35 cases). Both groups underwent intracranial aneurysm clipping. In the observation group, the Liliequist membrane was opened during the operation, while in the control group, the Liliequist membrane was not opened during the operation. The clinical effects of the two groups were compared; The scores of Glasgow Coma Scale (GCS), Modified Rankin Scale (mRS) and Montreal Cognitive Assessment Scale (MoCA) were compared between the two groups before operation and one month after operation; Serum levels of matrix metalloproteinase-9 (MMP-9), high mobility group protein 1 (HMGB1), vascular endothelial growth factor (VEGF) and postoperative complications were compared before and one month after surgery.【Results】Compared with the control group (60.00%), the total effective rate of the observation group (82.86%) was higher (P<0.05); After operation, GCS and MoCA scores were improved, while mRS scores were decreased in both groups (P<0.05); After operation, compared with the control group, the GCS and MoCA scores of the observation group were higher, while the mRS scores were lower (P<0.05); After operation, the level of MMP-9 increased, while the levels of HMGB1 and VEGF decreased in both groups (P<0.05); After operation, the levels of MMP-9, HMGB1 and VEGF in the observation group were lower than those in the control group (P<0.05); Compared with the control group (37.14%), the incidence of postoperative complications in the observation group (14.29%) was lower (P<0.05). 【Conclusion】In the treatment of aneurysmal subarachnoid hemorrhage with aneurysm clipping, opening the Liliequist membrane during the operation can improve the therapeutic efficiency, improve the cognitive function and prognosis of patients, and reduce the incidence of hydrocephalus and other complications.

Key words： Subarachnoid Hemorrhage/SU Intracranial Aneurysm/CO Microsurgery

Received: 18 April 2022

PACS:

R743.35

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	CHEN Bin
	ZHANG Dong-zi

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CHEN Bin,ZHANG Dong-zi. Effects of Different Treatments of Liliequist Membrane on the Risk of Complications in Patients with Aneurysmal Subarachnoid Hemorrhage[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1471-1473.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.10.009 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I10/1471

[1] TAWK R G,HASAN T F,D'SOUZA C E,et al. diagnosis and treatment of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage[J].Mayo Clin Proc,2021,96(7):1970-2000.
[2] CAO Y,LI Y,HE C,et al. Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage[J].Neurosci Bull,2021,37(4):535-549.
[3] BSAT S,CHANBOUR H,BSAT A,et al. Clinical utility of degradomics as predictors of complications and clinical outcome in aneurysmal subarachnoid hemorrhage[J].J Integr Neurosci,2021,20(2):489-497.
[4] 李伟光,彭玉平,漆松涛,等.神经内镜下三脑室底造瘘术治疗交通性脑积水的影像分析[J].中国神经精神疾病杂志,2009,35(5):285-288.
[5] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组,中华医学会神经病学分会神经血管介入协作组.中国蛛网膜下腔出血诊治指南2019[J].中华神经科杂志,2019,52(12):1006-1021.
[6] 吉沥.GOS评分在动脉瘤性蛛网膜下腔出血患者预后评估中的作用及其危险因素分析[J].空军医学杂志,2019,35(6):503-505.
[7] DUBOSH N M,EDLOW J A. Diagnosis and initial emergency department management of subarachnoid hemorrhage[J].Emerg Med Clin North Am,2021,39(1):87-99.
[8] 冯磊,谢利平,王鹏.动脉瘤性蛛网膜下腔出血患者脑脊液HMGB1、NSE水平变化及与脑积水的关系[J].河北医药,2019,41(18):2798-2801.
[9] 王双豹,冯国强,赵伟然,等.术中打开Liliequist膜对动脉瘤性蛛网膜下腔出血所致慢性脑积水的预防研究[J].西北国防医学杂志,2015,36(3):186-187.
[10] 毛湘渝.脑出血患者血浆及血肿引流液中MM-9水平的动态变化及其意义[J].医学临床研究,2009,26(6):1027-1029.
[11] Geiseler S J,Morland C. The janus face of VEGF in stroke[J].Int J Mol Sci,2018,19(5):1362.
[12] WINKLER E A,BURKHARDT J K,RUTLEDGE W C,et al. Reduction of shunt dependency rates following aneurysmal subarachnoid hemorrhage by tandem fenestration of the lamina terminalis and membrane of Liliequist during microsurgical aneurysm repair[J].J Neurosurg,2018,129(5):1166-1172.