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| Curative Effect of Lugua Polypeptide Injection on Knee Osteoarthritis |
| LI Sheng, LIU Xue-mei, LYU Wen-hao |
| Department of Pharmacy,Shandong Provincial Third Hospital,Jinan Shandong 250031 |
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Abstract 【Objective】To explore the efficacy of Lugua polypeptide injection in the treatment of knee osteoarthritis (KOA).【Methods】A total of 110 patients with KOA in our hospital were randomly divided into the observation group and the control group,with 55 cases in each group.The control group was treated with routine therapy,while the observation group was treated with intra-articular injection of Lugua polypeptide on the basis of the control group.The total effective rate,Lequesne score,laboratory related indexes (ESR,CRP,COX-2,IL-6),the level of interleukin-18 (IL-18),and matrix metalloproteinase-13 (MMP-13) in synovial fluid were compared between the two groups after treatment.【Results】The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).The scores of pain or discomfort,morning stiffness or pain after getting up,discomfort during walking,maximum walking distance and daily activity score in the two groups after treatment were significantly lower than those before treatment (P<0.05),and the above scores in the observation group after treatment were significantly lower than those in the control group (P<0.05).The levels of serum ESR,CRP,COX-2 and IL-6 in the two groups after treatment were significantly lower than those before treatment (P<0.05),and the levels of the above indicators in the observation group after treatment were significantly lower than those in the control group (P<0.05).After treatment,the levels of IL-18 and MMP-13 in synovial fluid of the two groups were significantly lower than those before treatment (P<0.05),and their levels in the observation group were significantly lower than those in the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Lugua polypeptide injection has a significant effect in the treatment of KOA,which can improve relevant symptoms and laboratory indicators,reduce the levels of IL-18 and MMP-13 in synovial fluid.The incidence of adverse reactions has not increased significantly.
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Received: 14 January 2022
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2022, Vol. 39 
